Chronic Invasive Nongranulomatous Fungal Rhinosinusitis in Immunocompetent Individuals

Table 1

Characteristics and outcome of the patients.

	Case	Case	Case	Case
Age/gender	58 yrs/male	43 yrs/male	60 yrs/female	68 yrs/male
Immune suppression	−	−	−	−
Symptom onset to diagnosis	6 months	24 months	9 months	6 months
Symptoms at presentation	Left orbital pain	Nasal obstruction	Dizziness	Headache
	Swelling on the face	Headache	Headache	Left retroorbital pain
	Nasal obstruction	Facial pain	Postnasal drip
Anatomic subsite involvement
Nasal cavity	+	+	−	−
Osteomeatal complex	+	+	−	−
Maxillary sinus	+	−	−	−
Ethmoidal sinuses	+	+	+ (right posterior)	+ (right posterior)
Sphenoid sinus	+ (left side)	+ (left side)	+ (right side)	+ (right side)
Frontal sinus	+	+	−	−
Bilateral involvement	−	−	−	−
Orbital involvement	LP destruction	LP destruction	−	−
Intracranial extension	−	−	+	−
Surgical treatment	ESS	ESS combined with external frontal sinus surgery	ESS	ESS
Organism
Microbiology	A. fumigatus	A. flavus	A. fumigatus	−
Histopathology	Nongranulomatous CIFRS	Nongranulomatous CIFRS	Nongranulomatous CIFRS	Nongranulomatous CIFRS
Medical treatment
Voriconazole	+	+	+	+
Follow-up time	10 months	8 months	7 months	5 months
Disease recurrence	−	−	−	−

LP: lamina papyracea, ESS: endoscopic sinus surgery, and CIFRS: chronic invasive fungal rhinosinusitis.