Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature

Table 1

Clinical information of adult patient’s onset who developed SCC and was reported in the English language literature.

Author(s), year	Age	Gender	RRP	Risk factors	HPV
Byhardt et al, 1988 [6]	61	Male	Yes	Smoker and Rxt	NR
Kashima et al, 1988 [7]	28	Male	Yes	Rxt	6
Zarod et al, 1988 [8]	72	Female	Yes	NR	6
Lindeberg et al, 1989 [9]	62.5	Male	Yes	Smoker	Negative
Lindeberg et al, 1989 [9]	34.4	Male	Yes	NR	Negative
Hasan et al, 1995 [10]	30	Male	Yes	Nonsmoker, without Rxt	NR
Pou et al, 1995 [11]	46	Male	Yes	Nonsmoker	16
Sakakura et al, 1996 [12]	63	Female	Yes	Nonsmoker	18
Klozar et al, 1997 [13]	81	Male	Yes	NR	NR
Klozar et al, 1997 [13]	58	Female	Yes	NR	NR
Klozar et al, 1997 [13]	56	Male	No	NR	NR
Behl et al, 2001 [14]	28	Male	Yes	Nonsmoker	NR
Azadamaki et al, 2013 [15]	77	Male	Yes	Nonsmoker	NR
Hao et al, 2013 [16]	52	Male	No	Passive smoker	16/18
Hasegawa et al, 2013 [17]	75	Male	Yes	NR	11
Jeong et al, 2009 [18]	55	Male	Yes	NR	6, 11
Jeong et al, 2009 [18]	64	Male	Yes	NR	NR
Ilmarinen et al, 2014 [19]	—	Male	Yes	7 smokers, 2 nonsmokers	NR
Zhang et al, 2015 [20]	43	Male	No	Multiple sex partners, second-hand smoker	NR
Present study	47	Male	No	No	16/18

RRP: recurrent respiratory papillomatosis; Rxt: radiotherapy; NR: not reported. The authors described 9 cases of malignancy, all were male and the mean age was 62 years (range: 41–79).