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Case Reports in Otolaryngology
Volume 2018 (2018), Article ID 5965029, 4 pages
Case Report

A Very Rare Case of Hypereosinophilic Syndrome Secondary to Natural Killer/T-Cell Lymphoma

1Department of Otorhinolaryngology and Head & Neck Surgery, University of Yamanashi, Yamanashi, Japan
2Department of Otorhinolaryngology and Allergy Center, Saitama Medical University, Saitama, Japan
3Department of Pathology, University of Yamanashi, Yamanashi, Japan
4Department of Hematology and Oncology, University of Yamanashi, Yamanashi, Japan
5Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan

Correspondence should be addressed to Takanori Yamamoto; pj.oc.oohay@kcitstaeb

Received 28 August 2017; Revised 6 February 2018; Accepted 18 February 2018; Published 26 March 2018

Academic Editor: Rong-San Jiang

Copyright © 2018 Takanori Yamamoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hypereosinophilic syndrome (HES) is a systemic disease characterized by an increased peripheral blood eosinophil count accompanied by systemic organ dysfunction. HES is classified into idiopathic HES, primary (neoplastic) HES (HESN), and secondary (reactive) HES (HESR). In this case report, a patient who developed peripheral blood eosinophilia and granulation tissue in the pharynx and paranasal sinus, which was initially diagnosed as chronic eosinophilic leukemia (CEL), categorized as HESN, but was eventually identified after the patient had died as natural killer/T-cell (NK/T) lymphoma, nasal type (ENKL), categorized as HESR, is presented. ENKL-induced HES is very rare but must be considered.