Bilateral Facial Paralysis and Deafness in a Child Treated for Acute Lymphoblastic Leukemia

Table 1

Literature review.

Study, year	No. of patients	Age of patients	Disease	Facial paralysis (FP) side	Otological surgery	Middle ear biopsy	Outcome of FP with chemotherapy
Todd and Bowman, 1984 [5]	1	13 yr	AML	Right	Yes	Granulocytic sarcoma	Complete resolution 6-month follow-up
Levy et al., 1986 [15]	1	5	AML	Right	Yes	Leukemic infiltration	Complete resolution
Ingram, 1990	9	ND	ALL	ND	No	—	ND
Zappia et al., 1990 [19]	1	6 yr	AML	Left	Yes	Granulocytic sarcoma	Complete resolution in 3-month follow-up
Juhn and Inoue, 1996 [20]	1	14 yr	T-cell ALL	Bilateral (alternately)	No	No	ND
Eser et al., 2001 [21]	1	14 yr	AML	AML	No	No	Complete resolution
Buyukavci et al., 2002 [13]	1	13 yr	T-cell ALL	Bilateral	No	No	Partial resolution
Krishnamurthy et al., 2002 [17]	1	11 mo	ALL	Bilateral	Yes	No	Improvement in 6-month follow-up
	1	11 mo	AML	Right	No	No	No improvement
	1	6 yr	ALL (Burkitt’s)	Left	No	No	Improvement in 6-month follow-up
Antunes et al., 2004 [16]	1	18 yr	ALL	Bilateral	No	No	No improvement
Bilavsky, 2006	1	8 mo	AML	Right	No	No	ND
Lakhotia et al., 2015 [14]	1	15 yr	Pre-B-cell ALL	Bilateral	No	No	No improvement
Li et al., 2016 [22]	1	11 yr	T-cell LBL	Right	Yes	Lymphoma	Complete resolution
Berger et al., 2016 [18]	1	8 yr	B-cell ALL	Bilateral	Yes	No	Partial resolution
Young et al., 2016 [23]	1	2 yr	AML	Bilateral	No	No	Improvement in 5-month follow-up
Chiang et al., 2017 [24]	1	12 yr	T-cell ALL	Right	No	No	Complete resolution
Sagar et al., 2018 [25]	1	6 yr	AML	Right	Yes	Leukemic infiltration	Complete resolution

Abbreviations: ALL: acute lymphoblastic leukemia, AML: acute myeloid leukemia, LBL: lymphoblastic lymphoma, ND: no description.