Lymphoepithelial Carcinoma Originated from the Sinonasal Cavity: Case Report and Literature Review

Table 1

Summary of previously reported cases of sinonasal lymphoepithelial carcinoma (SNLEC).

Authors	Age/gender	Race	Site of lesion	IHC	Stage	Surgery	Radiation	Chemotherapy	Survival/recurrence
Hajiioannou et al. [6]	33/M	NR	Nasal cavity, ethmoid sinus with frontal lobe invasion	+p40, rare focal	T4bN0M0 stage IVB	No	66 Gy	5-fluorouracil and cisplatin	Complete tumor response
				+p63, rare focal + EBV
				+Cytokeratins
				MNF116 and EMA
Rytkönen et al. [12]	30/M	NR	Maxillary sinus, soft palate/uvula with regional LN metastases	+Cytokeratin	T2N0M0 stage II	Yes	70 Gy	Cisplatin	11-month follow-up, no recurrence
				+CD45 (among lymphoplasmacytic infiltrate)
				+AE1/AE3
				−EBV
Tam et al. [13]	61/F	NR	Nasolacrimal duct	+EBV	NR	Enbloc resection with medial maxillectomy	64 Gy	No	33-month follow-up, no recurrence
Takakura et al. [14]	63/M	Japanese	Maxillary sinus	+Pancytokeratin, cytokeratin 14	T3N2bM0 stage IVA	Denker’s operation	36 + 34 Gy	5-Fluorouracil and nedaplatin	Disease-free for 5 years following operation
				+EBV
Mohammed et al. [8]	72/F	Caucasian	Maxillary sinus	+Pancytokeratin marker (MF116) +CK5/6, slight	T1N0M0 stage I	Radical excision of the mass	48 Gy	No	3-years follow-up, no recurrence
				−CK7, CEA, Melan, CK20, EBV
Jung et al. [15]	64/F	Asian	Maxillary sinus	+Pancytokeratin	T3N0M0 stage III	Enbloc sparing periorbita	6300 cGy	Docetaxel and carboplatin	3-year-follow-up, no recurrence
				−EBV
Muthayam et al. [16]	45/F	Indian	Maxillary sinus with LN metastases	+Pancytokeratin, diffuse	T3N0M0 stage III	No	70 Gy	No	20-month follow-up, no recurrence
				−Melanin A, CK20, EBV
Kim et al. [17]	21/M	NR	Nasal cavity	+Cytokeratin, CK5/6	T2N0M0 stage II	Endoscopic surgical excision	IMRT, 6996 cGy	Cisplatin	15-month follow-up, no recurrence
				+EBV
Mahawar and Devi [4]	76/M	NR	Maxillary sinus	+Cytokeratin	NR	No	EBRT, 7000 cGy	No	Currently under treatment
Rahim et al. [18]	32/F	Chinese	Nasopharynx	+MNF 116	NR	Endoscopic excision	NR	NR	NR
				+EBV
Wöckel and Wernert [19]	56/M	NR	Meatus of the nose	+Keratin	T1N0M0 stage I	Excision	No	No	No recurrence
				−EBV
Bonnerup et al. [10]	77/M	Caucasian	Sinonasal	+Pankeratin	T4aN2cMI stage IVC	NR	NR	Cisplatin and docetaxel	Excellent tumor response after two cycles
				+CK5/6
				+EMA (patchy)
				+EBV, strong and diffuse
Trabelsi et al. [9]	58/M	Tunisian	Nasal septum with orbital invasion	+Cytokeratin, EMA	T3N0M0 stage III	No	72 Gy	Adriamycin and cisplatin	12-month follow-up, no recurrence
				+EBV latent membrane protein 1

M: male; F: female; NR: not reported; IHC: immunohistochemistry; EPV: Epstein–Barr virus; CK: cytokeratin; EMA: epithelial membrane antigen; Gy: gray; CEA: carcinoembryonic antigen; LN: lymph node; IMRT: intensity-modulated radiotherapy; EBRT: external beam radiotherapy.