Transdural Skull Base Infiltration by Glioblastoma: Case Report and Review of the Literature

Figure 3

(a) HE staining showing a malignant glial tumor with histomorphological features of a glioblastoma, IDH wild-type (CNS WHO Grade 4). Black arrow: palisading necrosis. White arrows: microvascular proliferation. (b) The tumor shows areas with close association to fragments of the dura (black arrow) and bone (white arrow) (HE staining). (c) GFAP immunohistochemistry confirms the glial tumor cells. (d) No IDH1 mutation (R132H); inset in (d) on slide positive control. (e) Ki67 immunostaining highlights increased proliferation activity.

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