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Case Reports in Pathology
Volume 2014, Article ID 657497, 3 pages
http://dx.doi.org/10.1155/2014/657497
Case Report

Primary Synovial Sarcoma of Kidney: A Rare Differential Diagnosis of Renomegaly

1Department of Medical and Pediatric Oncology, GCRI, Ahmedabad, Gujarat 830016, India
2Department of Radiotherapy, Government Medical College, Haldwani, Nainital, Uttarakhand 263129, India

Received 1 November 2014; Accepted 9 December 2014; Published 24 December 2014

Academic Editor: Piero Tosi

Copyright © 2014 Gaurang Modi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Synovial sarcomas (SS) are classified as subgroup of soft tissue sarcomas affecting mainly extremities of young adults. Primary SS of kidney are very rare tumours with poor prognosis. Though they have characteristic histology and immunohistochemistry (IHC) due to rarity of incidence it is difficult to diagnose them. Sometimes chromosomal rearrangement studies are required to confirm the diagnosis. We are presenting a case of 41-year-old male who was referred to our cancer centre for evaluation of left renal mass. CT scan of abdomen revealed a large left renal mass encasing the aorta. Biopsy of renal mass revealed poorly differentiated sarcoma and IHC was positive for vimentin, CD99, and BCL2 and negative for AE1, epithelial membrane antigen, and leukocyte common antigen. The patient was clinically inoperable as renal mass was encasing the aorta. So he was subsequently offered palliative chemotherapy in form of ifosfamide and adriamycin. CT abdomen shows partial response after 3 cycles of chemotherapy according to RECIST criteria.