Case Reports in Pathology

Case Reports in Pathology / 2019 / Article

Case Report | Open Access

Volume 2019 |Article ID 2074504 | https://doi.org/10.1155/2019/2074504

Durga Paudel, Michiko Nishimura, Bhoj Raj Adhikari, Daichi Hiraki, Aya Onishi, Tetsuro Morikawa, Puja Neopane, Sarita Giri, Koki Yoshida, Jun Sato, Masayuki Ono, Yoshitaka Kamino, Hiroki Nagayasu, Yoshihiro Abiko, "Secretory Carcinoma of Minor Salivary Gland in Buccal Mucosa: A Case Report and Review of the Literature", Case Reports in Pathology, vol. 2019, Article ID 2074504, 8 pages, 2019. https://doi.org/10.1155/2019/2074504

Secretory Carcinoma of Minor Salivary Gland in Buccal Mucosa: A Case Report and Review of the Literature

Academic Editor: Janina Kulka
Received05 Feb 2019
Revised13 Mar 2019
Accepted18 Mar 2019
Published27 Mar 2019

Abstract

Secretory carcinoma (SC) of the salivary gland was recently added to the fourth edition of the World Health Organization classification of head and neck tumors. Some salivary tumors, including acinic cell carcinoma, have been reclassified as SC. Most of these tumors are located on the parotid gland with very few cases reported in the minor salivary glands of the buccal mucosa. Herein, we present a case of SC of buccal mucosa, which appeared clinically as a benign lesion in a 54-year-old Japanese female patient. Histopathologically, the tumor cells presented with an eosinophilic cytoplasm with microcytic structure along with eosinophilic secretory material and hemosiderin deposit. Immunohistochemical staining revealed strongly positive staining for S100, vimentin, and mammaglobin and negative staining for DOG-1. The tumor was finally diagnosed as secretory carcinoma of the buccal mucosa. We present a review of the medical literature of SC arising from minor salivary glands. We found only 15 cases of SC of buccal mucosa out of 63 cases of SC in the minor salivary glands. They showed good prognoses and only one case of SC in the buccal mucosa exhibited local recurrence and lymph node metastases.

1. Introduction

Secretory carcinoma (SC) is a rare salivary gland tumor and has been recently included in the fourth edition of the World Health Organization classification of head and neck tumors [1]. It is also known as mammary analogue secretory carcinoma since initially described by Skalova A et al. in 2010 through a series of 16 cases [2]. Most of the cases of this carcinoma have been located in the parotid gland, and only some were reported in minor salivary glands [24]. Herein, we report a case of SC in the minor salivary gland of the buccal mucosa and present a review of the medical literature regarding this condition.

2. Case Presentation

A 54-year-old Japanese female visited an oral surgery clinic with a complaint of swelling in the inner region of the left cheek for the past one month. On clinical examination, a mobile swelling (size, 1 cm x 0.75 cm) with a clear boundary was observed on the left buccal mucosa. No associated pain was reported and the overlying mucosa was normal in appearance. The swelling was clinically diagnosed as benign buccal mucosa tumor. The tumor was excised under local anesthesia and was diagnosed as acinic cell carcinoma (AcCC) after histopathological examination. The margins were still positive for the tumor and further resection was advised. The patient reported to the Health Sciences University of Hokkaido Hospital for resection of the residual tumor two months after the initial surgery. Clinically, the patient was asymptomatic. The level 1B lymph nodes on both sides were palpable, bean sized, mobile, elastic, and soft. Intraorally, a surgical scar of about 7 mm was present on left buccal mucosa. There was no pain on pressure in the region of the scar (Figure 1(a)). The patient had a history of noninvasive ductal carcinoma (ductal carcinoma in situ [DCIS]; T N0M0) in the right breast, which was treated by excision and 57 Gy of radiotherapy five months ago. On investigation for oral lesion, no obvious abnormalities were detected on the computed tomography- (CT-) scan, contrast MRI, and ultrasonogram. Positron emission tomography- (PET-) CT did not suggest transition to and from any of the distant organs. The margin was resected under general anesthesia and sent for histopathological examination (Figure 1(b)). No relation to the parotid gland was found at the time of surgery.

Histopathologically, the excised margin appeared as a fragmented tissue with no encapsulation. The tumor tissue was composed of cells with dominant microcystic structure with eosinophilic cytoplasm and eosinophilic secretory material. Papillary and tubular pattern of cell arrangement were also found but were limited to small area. A few vacuolar cells and some areas with hemosiderin deposition were observed. Furthermore, normal muscle tissue and atrophied salivary gland tissues were also seen (Figure 2).

The secretory material was positive for diastase digested Periodic acid-Schiff (d-PAS), Mucicarmine, and Alcian Blue staining. No zymogen granules were found in the tumor cells. Immunohistochemistry (IHC) revealed strong positive reactions to vimentin, cytokeratin-19, and S100 protein. Mammaglobin was strongly positive, whereas discovered on gastrointestinal stromal tumors 1 (DOG-1) showed a negative reaction (Figure 3). The histological sections of breast carcinoma were examined in suspicion of metastases; however, features of ductal carcinoma in situ that appeared completely different from those of buccal mucosa tumor were noted. Based on these histomorphologic and IHC profiles, the case was diagnosed as SC of the minor salivary gland in the buccal mucosa.

3. Discussion

SC of salivary glands has been recently included in the fourth edition of the World Health Organization classification of head and neck tumors [1]. Since its description by Skalova et al. in 2010, some salivary tumors, including AcCC, have been reclassified as SC [2]. The majority of these cases were found in major salivary glands, with less frequency in minor salivary glands [24]. Our review showed that 63 cases of SC of minor salivary glands have been reported (Table 1). Among them, only 15 cases were found in buccal mucosa. The lip was the most affected site (21 cases) followed by palate (17 cases). Two cases were reported in tongue, labial mucosa, and retro molar gingiva each and 1 case in floor of mouth. The mean age of these patients was 48.1 years (range: 5-86 years). Only 2 cases were found in pediatric population [13, 18]. The sizes of the tumors ranged between 0.3 and 3.0 cm (mean 1.2cm). Among 42 cases which specified tumor size, more than half (24 cases) were of size 1 cm. Only 6 cases which were 2 cm were reported. Most of the tumors presented as a slow growing and painless mass. The only aggressive tumor was in hard palate which showed slow growth for 36 months but was aggressive for 2 months [23]. Two patients with tumor at hard palate complained of pain with ulceration [15, 22]. Lymph node metastases occurred in only 4 patients [2, 6, 23, 28] and local recurrence was reported in 4 patients [7, 23, 28]. These clinical features indicate that SC in the minor salivary glands may have a good prognosis with rare recurrence and lymph node metastases.


AuthorSiteAge/SexClinical course (Duration)SizeLNI / DMTreatmentFollow-up (Duration)

Abe M, 2015 [5]Upper lip61/FPainless mass (1 year)0.8NANANA

Aizawa T, 2016 [6]Lower lip41/MSlow growth, painless (3 mo)1.5x1.3-/-SLNM (26 mo)

Bishop JA, 2013 [7] Buccal mucosa71/M NA1.0-/-SOnly 1 case of upper lip locally recurred.
Mean follow-up: 42 mo (4-85mo)
Hard Palate25/FNA-/-S
Soft Palate20/F0.9-/-S
Soft Palate86/F1.0-/-S
Soft Palate79/F0.7-/-S
Upper lip62/F0.3-/-S
Upper lip71/M0.6-/-S
Lower lip59/M0.9-/-S
Lower lip68/M0.5-/-S

Bissinger O, 2017 [8] Floor of mouth34/M0.8-/-SNo recurrence

Chiosea SI, 2012 [4] Soft palate-3 case, Buccal mucosa – 2 case, Tongue base- 1 case. Further clinical data not available

Connor A, 2012 [9] Oral cavity (NS)Mean:40 y
(14-77y)
NA1.8-/-S NA
Roof of mouth0.5-/-S
Inner cheekNA-/-S
Lip1.2-/-S

Cooper D, 2013 [10] Soft palate43/MSlow growing, painless2.5-/-SNo recurrence (14 mo)
Soft palate26/FPainless (7 mo)0.7-/-SNo recurrence (24 mo)

Din NU, 2016 [11] Buccal mucosa NA

Fehr A, 2011 [12] Soft Palate71/F NA
Oral mucosa43/M

Griffith C, 2011 [13] Upper lip15/M NANA-/-NANA

Guilmette J, 2017 [14] Buccal mucosa64/F NA0.6-/-NANA

Helkamaa T, 2015 [15] Hard palate35/MUlcerated, tender (6 mo)2.0x1.5-/-SNo recurrence (18 mo)

Hindocha N, 2017 [16] Upper lip27/FSlow growing (1y)1.5-/-SNo recurrence
Labial mucosa51/MAsymptomatic, firm (3y)-/-SNo recurrence

Kai K, 2017 [17] Buccal mucosa58/M NA3.0NASNo recurrence (1 y)

Keishling M, 2014 [18] Buccal mucosa5/F(4mo)1.5x1.5x1.3-/-SNA

Khurram SA, 2017 [19] Buccal mucosa, Lower lip and Soft palate- 1 case each. Further clinical data not available.

Kratochvil FJ, 2012 [20] Upper lip48/MSlow growth, painless1.0-/-SNo recurrence (8 mo)
Labial mucosa52/MPainless0.7x0.3-/-SNo recurrence (4 mo)

Laco J, 2013 [21] Upper lip34/FSlow growing, painless (2y)1.5-/-SNo recurrence (15 mo)

Luo W, 2014 [22] Hard palate41/FUlcerated crater2.0+/-S+RNo recurrence (10 mo)

Majewska H, 2015 [23] Hard palate54/MSlow growing, non tender (36 mo), aggressive (2 mo)2.0x1.0-/-S+RLocal recurrence (48 mo), LNM

Mariano FV, 2016 [24] and Projetti F, 2015 [25] each reported 1 case (no site specified). Further clinical data not available.

Roy S, 2018 [26] Upper lip54/MSlow growing, painless1.5-/-SNA
Tongue22/F NA1.5x1.5x1NASNA

Serrano ML, 2015 [27] Buccal mucosa41/FSlow growing0.5NANANA
Buccal mucosa50/MSlow growing0.5NANANA

Skalova A, 2010 [2] Buccal mucosa51/FSlow growing, painless (1y)1.0-/-SNo recurrence (4 y)
Soft palate48/MSlow growing1.0x1.5-/-SNo recurrence (9y)
Upper lip32/MPainless but grew in size1.0-/-S+RLNM (86 mo)

Skalova A, 2016 [28] Buccal mucosa31/F NA1.0-/-SNo recurrence (11 mo)
Buccal mucosa24/F1.0+/-SLNM, Local recurrence (2y)
Upper lip48/M1.0-/-SLocal recurrence (2 mo)
Lip50/M1.5NANANA
Retromolar gingiva69/F0.6-/-SNo recurrence (2y)
Retromolar gingiva73/M1.5x2.0x2.5+/-NANA
Lip62/F1.0-/-SNo recurrence (3 y)

Steven TM, 2015 [29] Upper lip44/F NANANASNA
Lower lip66/M NANANASNA
Hard palate54/M NANANAS+RNo recurrence (2 y)

Urano M, 2015 [30] Lip40/M(3 mo)1.2x1.1-/-NANo recurrence

Zardawi IM, 2014 [31] Upper lip66/M(6 mo)1.2x1.0x.08-/-SNo recurrence

LNI / DM: Lymph node involvement / Distant metastases before treatment, S: Surgery, R: Adjuvant radiotherapy, LNM: Lymph node metastases on follow-up, mo: Month, y: Year, NA: Data not available, +/-: Present/Absent

The present case was clinically diagnosed with benign buccal mucosa tumor. The small size of the tumor with a regular border, slow growth, normal overlying mucosa, and absence of pain suggested the lesion might be benign. Therefore, the resection margins were maintained close to the tumor. However, the margins were positive on histopathological examination, necessitating additional surgery for removal of residual tumor, which was subsequently diagnosed as SC. This discrepancy in clinical and pathological diagnosis might be due to the indolent clinical behavior of SC arising in the minor salivary gland of buccal mucosa. Our case needed to be ruled out for metastases from breast carcinoma since the patient had a history of breast DCIS. The PET-CT did not show any signs of metastases, and the histopathological sections of breast DCIS appeared completely different from the SC in the buccal mucosa. The possibility of metastasis of the breast carcinoma could be completely ruled out.

The differential diagnosis of SC includes AcCC, low-grade cribriform cystadenocarcinoma, low-grade mucoepidermoid carcinoma, and polymorphous low-grade adenocarcinoma [3]. Most of the cases of SC were previously diagnosed as AcCC because of their histopathological similarities. Nevertheless, some histomorphological findings are more common in SC than in AcCC. Few authors reported that the presence of papillary cystic and microcystic patterns with vacuolated cells is characteristic of SC [32, 33]. Hemosiderin deposition was also more commonly observed in SC than in AcCC [34]. In the present case, the absence of zymogen granules and presence of microcystic pattern with eosinophilic cytoplasm and eosinophilic secretory material were suggestive of SC rather than AcCC. Few areas of hemosiderin deposition along with vacuolated cells and the papillary cystic arrangement of cell also favored a diagnosis toward SC rather than AcCC.

The sections stained positive for cytokeratin-19, S100 protein, vimentin, and mammaglobin. S100 and vimentin were strongly expressed as has been reported earlier in SC. Mammaglobin is related to a family of secretory proteins; it is expressed in normal breast cells and overexpressed in carcinomatous breast cells [35]. Strong positive reaction to mammaglobin was noted in the present case, which suggested the presence of a mammary analogue secretory component in the tumor cells. The DOG-1 protein is known to be expressed in normal salivary gland tissues, especially in the apical portions of acinic cells and few areas of the intercalated duct cells [36]. This marker can be utilized to rule out the presence of the acinic component in suspected cases of SC. A negative reaction to DOG-1 was noted in the current case thereby ruling out a diagnosis of AcCC.

The histological, immunohistochemical, and genetic appearance of SC of salivary gland is similar to that of breast secretory carcinoma. A balanced translocation t (12:15) (p13: q25) resulting in ETV6-NTRK3 fusion is seen in SC [2]. Most cases have been confirmed by the demonstration of a break apart or fusion gene by fluorescence in situ hybridization or polymerase chain reaction. However, with increasing numbers of retrospective studies, it was demonstrated that the result of the histomorphologic features and IHC profile was sufficient to diagnose almost all cases of SC, while genetic analysis can be reserved for atypical cases [20, 37, 38].

4. Conclusion

This report presents a rare case of SC of buccal mucosa, which was benign in clinical presentation. In addition, a review of the medical literature regarding the clinical behavior of SC of minor salivary gland was performed.

Conflicts of Interest

The authors declare that there are no conflicts of interest regarding the publication of this article.

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Copyright © 2019 Durga Paudel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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