Involvement of Annexin A2 Expression and Apoptosis in Reverse Polarization of Invasive Micropapillary Carcinoma of the Breast

Figure 9

Immunohistochemistry of the tumor component showing partial detachment. (a) A cleft-like space without septa is found (arrowheads). Asterisks indicate lumens. H&E stain. (b) A stroma-facing surface of detached tumor cells shows a clear positivity (arrowheads). Moreover, the luminal surface, some rims of vacuoles, and intercellular membranes of the neighboring tumor cells show a distinct positivity. ANX A2 immunostain. (c) A distinct positivity is also seen at the stroma-facing surface of partially detached tumor cells, similarly to that of (b) (arrowheads). EMA immunostain. (d) The immunoreactivity similar to that of (c) is detected (arrowheads). MUC-1 immunostain. The scale bars indicate 50 μm.

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