Chronic Granulomatous Herpes Encephalitis in a Child with Clinically Intractable Epilepsy

Table 1

Histologically verified cases of chronic granulomatous herpes simplex encephalitis.

Source	Latency	Presentation	Treatment	Course
Jay et al. [6] (Pt. 2)	2.5 years	Intractable Seizures	Temporal lobectomy	Not available
Love et al. [4] (Pt. 1)	4.5 years	Intractable Seizures	Hemispherectomy	Marked Improvement
Love et al. [4] (Pt. 2)	10 years	Intractable Seizures	Temporal lobe excision × 2 + Acyclovir	Marked Improvement
Love et al. [4] (Pt. 3)	2 months	Congenital HSV2 Skin infection^*	Topical Acyclovir	Sudden death
Adamo et al. [7]	14 years	Intractable Seizures	Biopsy + Acyclovir	Marked Improvement
Current case	10 years	Intractable Seizures	Frontal lobectomy + Acyclovir	Minimal improvement

^*All cases had documentation of HSV1 infection except Patient 3 from Love et al. [4] who had congenital HSV2 infection eventuating in sudden death, with granulomatous herpes encephalitis diagnosed at autopsy.