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Case Reports in Pediatrics
Volume 2013, Article ID 514232, 3 pages
Case Report

Septicemia in a Neonate following Therapeutic Hypothermia: The Literature Review of Evidence

1Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F Clinical Sciences Building, Shatin, Hong Kong
2The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
3Department of Pediatrics, The University of Calgary, Calgary, AB, Canada T2M 0H5

Received 9 July 2013; Accepted 31 July 2013

Academic Editors: A. T. Soliman and A. Spalice

Copyright © 2013 Kam Lun Hon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report a term neonate with hypoxic ischemic encephalopathy who underwent a 72-hour therapeutic hypothermia. He developed unstable body temperature associated with coagulase negative staphylococcus septicemia 2 weeks later which was promptly treated with intravenous antibiotics and made a good recovery. PubMed (a service of the U.S. National Library of Medicine) was searched for the terms “therapeutic hypothermia” and “septicemia,” with limits activated (humans, English, age 0–18 years). There were only 6 randomized controlled trials, 1 non-randomized controlled trial, 1 retrospective cohort, and 1 case-control trial, which showed no definite evidence of increased risk of septicemia or neutrophil dysfunction in infants following hypothermia therapy.