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Case Reports in Pediatrics
Volume 2014, Article ID 831398, 3 pages
http://dx.doi.org/10.1155/2014/831398
Case Report

Cooccurrence of Darier’s Disease and Epilepsy: A Pediatric Case Report and Review of the Literature

1Pediatric Neurology, Adana Numune Research and Training Hospital, Adana, Turkey
2Pediatrics, Adana Numune Research and Training Hospital, Adana, Turkey
3Pathology Department, Adana Numune Research and Training Hospital, Adana, Turkey

Received 22 April 2014; Revised 20 August 2014; Accepted 21 August 2014; Published 1 September 2014

Academic Editor: Piero Pavone

Copyright © 2014 Tamer Celik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Darier’s disease is a skin disorder characterized by multiple eruptions of hyperkeratosis or crusted papules at seborrheic areas with histologic acantholysis and dyskeratosis. It is caused by mutations in a single gene, being ATP2A2 and that is expressed in the skin and brain. The cooccurrence of various neurologic and psychiatric diseases with Darier's disease has been reported frequently in literature. They include mood disorders, epilepsy, encephalopathy, and schizophrenia. In this study, we report a pediatric case with the cooccurrence of Darier’s disease and epilepsy. We also revised current English literature on this topic.