Case Report
Neonatal Hepatitis as First Manifestation of Hyperimmunoglobulinemia D Syndrome
Table 1
Investigations performed in the neonatal period.
| Examination | Test result |
| Haemoglobin (range) | 5.0–9.5 mmol/L | Leucocytes (highest) | 45 × 109/L | Thrombocytes (lowest) | 17 × 109/L | CRP (highest) | 110 mg/L | Bilirubin total (highest) | 552 µmol/L | Bilirubin conjugated (highest) | 392 µmol/L | ALAT (highest) | 281 U/L | Alkaline phosphatase (highest) | 483 U/L | Lactate dehydrogenase | 3235 U/L | Urate | 0.38 mmol/L | Lactate | 2.2 mmol/L | Blood culture | Negative | Blood smear | Extramedullary haematopoiesis no lymphoblasts | Bone marrow aspiration | No malignancy | CMV serology | Negative | CMV PCR in blood and urine | Negative | EBV serology | Negative | Toxoplasmosis serology | Negative | VZV serology | Negative | Urine metabolic screen | Normal | X-ray thorax | No infiltrates | X-ray abdomen | Normal | US abdomen | Marked hepatomegaly | CT thorax and abdomen | Marked hepatomegaly | US cerebrum | 2.2 × 2.5 cm echogenic process | CT cerebrum |
Haemorragia in posterior fossa | Electrocardiogram | Normal | Echocardiography | Normal | Lumbar puncture | Unsuccessful |
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