Neonatal Hepatitis as First Manifestation of Hyperimmunoglobulinemia D Syndrome

Table 2

Investigations performed in the outpatient clinic and at first acute hospitalisation in Denmark 3.5 years of age.

Investigation	Result
Haemoglobin	5.2 mmol/L
Leucocytes	10.9 × 10^9/L
Thrombocytes	505 × 10^9/L
CRP	142 mg/L
Erythrocyte sedimentation rate	72 mm/h
Iron	2 µmol/L (ref.: 5–20)
Haptoglobin	4.41 g/L (ref.: 0.35–1.85)
Transferrin	34 µmol/L (ref.: 24–41)
Urate	0.49 mmol/L (ref.: 0.15–0.35)
Lactate dehydrogenase	203 U/L (ref.: 155–450)
IgD	100 IU/mL
IgG	12.3 g/L (ref.: 3.4–9.1)
IgA	3.08 g/L (ref.: 0.12–1.49)
IgM	1.64 g/L (ref.: 0.39–2.08)
IgG subclasses	Normal
Blood culture	Negative
Blood smear	Reactive, no lymphoblasts
HIV antibodies	Negative
Complement defect screening	Normal
Vaccination response to HiB	1.41 µg/mL (ref.: >1 µg/mL)
Vaccination response to diphtheria	1.6 IE/mL (ref: >0.01 IE/mL)
Vaccination response to tetanus	0.98 IE/mL (ref: >0.1 IE/mL)
Mannan binding lectin (MBL)	220 µg/L
Haemoglobin electrophoresis	Normal
Tracheal aspirate	Moraxella catarrhalis
Chest X-ray	Discrete perihilar infiltrates
Urine culture	Negative