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Case Reports in Pediatrics
Volume 2015, Article ID 402137, 3 pages
http://dx.doi.org/10.1155/2015/402137
Case Report

Successful Treatment of Candida parapsilosis Fungemia in Two Preterms with Voriconazole

1Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Marmara University, 34890 Istanbul, Turkey
2Division of Pediatric Infectious Disease, Department of Pediatrics, Faculty of Medicine, Marmara University, 34890 Istanbul, Turkey

Received 22 February 2015; Accepted 21 May 2015

Academic Editor: Juan Manuel Mejía-Aranguré

Copyright © 2015 Emel Altuncu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Herein, we report two preterms with invasive candidiasis refractory to liposomal amphotericin B (AMB) treatment in spite of low MIC levels (MIC: 0.5 mcg/mL). Both of the patients’ blood cultures were persistently positive for C. parapsilosis despite high therapeutic doses (AMB: 7 mg/kg per day). After starting voriconazole blood cultures became negative and both of the patients were treated successfully without any side effects. In conclusion, although it is not a standard treatment in neonatal patients, our limited experience with these patients suggests that voriconazole appears to be a safe antifungal agent to be used in critically ill preterm infants with persistent fungemia despite AMB treatment.