Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Pediatrics
Volume 2015, Article ID 689206, 4 pages
Case Report

Multicentric Castleman’s Disease in a Child Revealed by Chronic Diarrhea

Unit of Pediatric Hematology-Oncology, Department of Pediatrics, University Hospital Hassan II, Faculty of Medicine and Pharmacy, University Sidi Mohamed Ben Abdellah of Fez, Morocco

Received 13 June 2014; Accepted 30 January 2015

Academic Editor: Josef Sykora

Copyright © 2015 Sarra Benmiloud et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Multicentric Castleman’s disease is a rare benign and unexplained lymphoproliferative disorder that is extremely uncommon in children. It presents with fever, systemic symptoms, generalized lymphadenopathy, and laboratory markers of inflammation. Its treatment is not standardized and its prognosis is poor. We report a novel case of multicentric Castleman’s disease in a 13-year-old girl who had presented with chronic diarrhea as the only initial presenting symptom. The diagnosis of celiac or inflammatory bowel diseases was suspected, but two and a half years later, the diagnosis of multicentric Castleman’s disease was brought following the appearance of abdominal mass whose biopsy revealed Castleman’s disease in the plasma cell form. The outcome was favorable after treatment by corticosteroid, chemotherapy, and surgery. The occurrence of diarrhea as the initial symptom of multicentric Castleman’s disease without lymph node involvement is very rare. This case report underlines the diagnostic difficulties and the long interval between onset and diagnosis when diarrhea occurs first.