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Case Reports in Pediatrics
Volume 2016, Article ID 2659389, 3 pages
http://dx.doi.org/10.1155/2016/2659389
Case Report

Ibuprofen for Ductus Arteriosus Months after Birth

1Division of Neonatology, Department of Pediatrics, Erasmus MC-Sophia Children’s Hospital, Wytemaweg 80, 3015 CN Rotterdam, Netherlands
2Division of Pediatric Cardiology, Department of Pediatrics, Erasmus MC-Sophia Children’s Hospital, Wytemaweg 80, 3015 CN Rotterdam, Netherlands

Received 19 January 2016; Revised 21 April 2016; Accepted 23 May 2016

Academic Editor: Jonathan Muraskas

Copyright © 2016 Odile Frauenfelder et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ibuprofen is a well-known agent used to treat patent ductus arteriosus in preterm neonates in the first days of life. In the current case report we illustrate the potential use of ibuprofen in two preterm neonates 60 and 88 days after birth, respectively. To our knowledge, this is the first report on the effects of ibuprofen on patent ductus arteriosus in preterm newborns after months of life. These cases suggest that the ductus arteriosus does not become refractory for ibuprofen after the first days of life. Late closure of the duct with ibuprofen might still improve the cardiorespiratory condition and prevent infants from surgical closure. Controlled trials are necessary to further study these findings.