Congenital Hypothyroidism: An Unusual Combination of Biochemical Abnormalities

Table 1

Results of serial biochemical investigations.

Day of life	Reference value	44	51	52	55	59	70
Day following initiation of therapy		−11	−4	−3	0	4	15
Serum bilirubin (total)	<1.2 mg/dl	14.9	16	15.2	14.6	16.3	3.8
Serum bilirubin (direct)	<0.2 mg/dl	1.1	1.3	1.3	1.3	1.1	0.9
Serum bilirubin (indirect)	1.0 mg/dl	13.8	14.7	13.9	13.3	15.2	2.9
Serum protein, total	5.1–7.3 g/dl	—	5.6	5.3	5.6	5.7	6.0
Serum albumin	2.2–4.8	—	3.4	3.3	3.4	3.6	4.1
SGOT (AST)	9–80 u/l	—	298	278	225	220	40
SGPT (ALT)	13–45 u/l	—	174	157	148	135	20
Serum alkaline phosphatase	150–420 u/l	—	239	213	226	221	247
Serum free T3	0.91–4.4 pg/ml	—	—	—	<1	—	4.1
Serum free T4	0.8–2.0 ng/dl	—	—	—	<0.4	—	1.4
TSH	0.8–8.2 microIU/ml	—	—	—	500	—	37.8