Anterior Hypopituitarism and Treatment Response in Hunter Syndrome: A Comparison of Two Patients

Figure 1

(a) Cranial MRI of Case 1 obtained at the age of 8 years reveals ectopic posterior pituitary lobe. Sagittal spin-echo T1-weighted image shows an abnormal, shallow sella turcica, as well as hypoplastic clivus. A normal T1-hyperintense posterior lobe of the pituitary gland is not identified in the sella turcica. Instead, a T1-hyperintense round structure (arrow) is noted inferior to the floor of third ventricle at the level of infundibular recess. A pituitary stalk is not seen. Prominent forehead related to macrocephaly is also noted. (b) Cranial MRI of Case 2 obtained at the age of 12 years reveals a large empty sella. Sagittal spin-echo T1-weighted image shows a markedly enlarged sella turcica filled with CSF. The anterior and posterior lobes of the pituitary gland (arrows) are displaced posteriorly. A hypoplastic clivus and prominent forehead are present.

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