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Case Reports in Pediatrics
Volume 2016, Article ID 7869174, 3 pages
Case Report

Mitochondrial Disorder Aggravated by Metoprolol

Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USA

Received 3 June 2016; Revised 12 September 2016; Accepted 3 October 2016

Academic Editor: Alberto Spalice

Copyright © 2016 Cheryl Samuels et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Beta-adrenergic blocking agents or beta-blockers are a class of medications used to treat cardiac arrhythmias and systemic hypertension. In therapeutic dosages, they have known adverse outcomes that can include muscular fatigue and cramping, dizziness, and dyspnea. In patients with mitochondrial disease, these effects can be amplified. Previous case reports have been published in the adult population; however, their impact in pediatric patients has not been reported. We describe a pediatric patient with a mitochondrial disorder who developed respiratory distress after metoprolol was prescribed for hypertension. As the patient improved with discontinuation of medication and no alternative etiology was found for symptoms, we surmise that administration of metoprolol aggravated his mitochondrial dysfunction, thus worsening underlying chest wall weakness.