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Case Reports in Pediatrics
Volume 2016, Article ID 9648043, 4 pages
http://dx.doi.org/10.1155/2016/9648043
Case Report

A Child with Local Lipohypertrophy following Recombinant Human Growth Hormone Administration

1Department of Pediatric Gastroenterology, Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands
2Pediatric Surgical Centre Amsterdam, VUMC/Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands
3Department of Pediatric Endocrinology, Emma Children’s Hospital, Academic Medical Center, Amsterdam, Netherlands

Received 7 July 2016; Accepted 19 September 2016

Academic Editor: Ashraf T. Soliman

Copyright © 2016 Ilan J. N. Koppen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Local lipohypertrophy due to recombinant human growth hormone (rhGH) administration is a rare phenomenon. Here, we report a case of an 11-year-old girl who presented with a paraumbilical swelling, approximately one year after the start of rhGH treatment for short stature due to the presumed diagnosis of partial growth hormone insensitivity. Ultrasound imaging revealed an asymmetric distribution of subcutaneous fat tissue at the rhGH administration site, indicating local lipohypertrophy. After sparing her routine injection site and alternating other sites, the swelling disappeared within 6 months. Although the precise cause of local lipohypertrophy resulting from rhGH administration is still unclear, it might be related to the presumed diagnosis of partial growth hormone insensitivity.