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Case Reports in Pediatrics
Volume 2017, Article ID 5437830, 5 pages
Case Report

Osteopathic Manipulative Treatment Limits Chronic Constipation in a Child with Pitt-Hopkins Syndrome

1Research Department, Istituto Superiore di Osteopatia, 20126 Milan, Italy
2Department of Clinical Paediatrics & Obstetrics-Gynaecology, Istituto Superiore di Osteopatia, 20126 Milan, Italy

Correspondence should be addressed to Alessandro Aquino; ti.iosi@oniuqa.ordnassela

Received 14 November 2016; Accepted 15 January 2017; Published 31 January 2017

Academic Editor: Seyed Mohsen Dehghani

Copyright © 2017 Alessandro Aquino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pitt-Hopkins Syndrome (PTHS) is a rare genetic disorder caused by insufficient expression of the TCF4 gene. Children with PTHS typically present with gastrointestinal disorders and early severe chronic constipation is frequently found (75%). Here we describe the case of a PTHS male 10-year-old patient with chronic constipation in whom Osteopathic Manipulative Treatment (OMT) resulted in improved bowel functions, as assessed by the diary, the QPGS-Form A Section C questionnaire, and the Paediatric Bristol Stool Form Scale. The authors suggested that OMT may be a valid tool to improve the defecation frequency and reduce enema administration in PTHS patients.