Case Reports in Pediatrics

Case Reports in Pediatrics / 2017 / Article

Case Report | Open Access

Volume 2017 |Article ID 6570465 |

Lisheng Lin, Miho Takahashi-Igari, Yoshiaki Kato, Yoshihiro Nozaki, Mana Obata, Hiromi Hamada, Hitoshi Horigome, "Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant", Case Reports in Pediatrics, vol. 2017, Article ID 6570465, 3 pages, 2017.

Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant

Academic Editor: Seyed Mohsen Dehghani
Received17 Feb 2017
Accepted02 May 2017
Published30 May 2017


We report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricular arrhythmias were confirmed after birth. Genetic testing of the baby revealed a SCN5A R1193Q variant, which we considered could account for the various arrhythmias in this case.

1. Introduction

Fetuses with trisomy 18 tend to present bradycardia, but further electrophysiological details have not fully been investigated [1, 2]. In the present case, bradycardia and atrioventricular block (AVB) were observed by fetal echocardiography. Further details such as QT interval prolongation and functional AVB due to prolonged ventricular repolarization were accurately diagnosed by fetal magnetocardiography (fMCG). A SCN5A gene variant (R1193Q) was identified after birth, which might have attributed to the complex arrhythmias in this patient.

2. Case Presentation

The mother was referred to our hospital at 20 weeks of gestation due to fetal bradycardia, fetal growth retardation, oligohydramnios, and overlapping fingers detected on fetal ultrasound. The fetus was suspected to have chromosomal abnormality, specifically trisomy 18. The parents chose not to carry out prenatal genetic diagnosis. Ventricular septal defect (VSD) and bradycardia with AVB were diagnosed by fetal echocardiography. At 28 weeks of gestation, fMCG (MC-6400, Hitachi High-Technologies Corporation) was performed to investigate the details of arrhythmias (Figure 1). Baseline fetal heart rate was around 66 beats per minute (bpm). QT interval was prolonged and 2 : 1 AVB was suspected to be the so-called functional AVB, which develops due to prominently prolonged ventricular repolarization (QT 0.498 s, QTc 0.522). Torsade de pointes or other ventricular arrhythmias were not detected. At the prenatal visit, parents were informed of the possibilities of (1) the need for urgent pacemaker therapy for bradycardia after birth and (2) the occurrence of lethal arrhythmias in late pregnancy or immediately after birth.

Fetal hydrops or signs of fetal heart failure were not detected before birth. The baby (male) was born at 37 weeks and 1 day of gestation with a birth weight of 1,211 g. The Apgar scores were 8 at 1 minute and 9 at 5 minutes. Characteristic multiple minor anomalies of trisomy 18 included prominent occiput, micrognathia, and short sternum. Chromosome analysis revealed the karyotype 47, XY, +18 (trisomy 18). A large VSD (inlet type, 4 mm) and patent ductus arteriosus were observed by transthoracic echocardiography. The baby’s resting heart rate was 60–70 bpm. A grade of 2 : 1 or higher (transiently, 3 : 1) AVB and QT interval prolongation were recorded on electrocardiogram (ECG) (Figures 2(a) and 2(b)). Nonsustained ventricular tachycardia was also observed (Figure 2(c)). Considering the poor prognosis of trisomy 18, the parents did not consent to aggressive treatments such as pacemaker implantation for bradycardia nor surgical closure of VSD. The patient died at 85 days postnatally, because of progressive heart failure.

Informed consent was obtained from the parents and genetic analysis of long QT candidate genes was performed (Ion PGM™ system, target exon sequencing, and direct sequencing). A SCN5A R1193Q variant was identified, which we considered could account for the various arrhythmias observed in this case [35].

3. Discussion

Trisomy 18 syndrome is usually associated with multiorgan complications and has a poor prognosis. Meanwhile, reports of its electrophysiological details are very few, and whether or not trisomy 18 has arrhythmic substrates is still unknown. To the best of our knowledge, this is the first report to describe complex arrhythmias in trisomy 18. On the other hand, SCN5A R1193Q (amino acid substitution of glutamine for arginine), which was identified in this case, is a variant that alters the current of cardiac sodium channel [5]. The R1193Q variant in SCN5A has been associated with sudden infant death syndrome (SIDS), long QT syndrome (LQTS) type 3, cardiac conduct defect, and Brugada syndrome [3, 4, 7, 8], and we consider it to be partly responsible for the various arrhythmias that were observed in this case. However, there was no previous report of coexistence of SCN5A mutation and trisomy 18. We believe that the coexistent SCN5A R1193Q variant in this case was coincidental.

fMCG makes it possible to noninvasively record weak electrical activities of the fetal heart, enabling the measurement of QT intervals of the fetus, and is therefore helpful for differential diagnosis of fetal arrhythmias, including long QT syndrome [9, 10]. In the present case, using fMCG, we made an accurate diagnosis of complex arrhythmias that consisted of sinus bradycardia, AVB, and QT interval prolongation. Based on the detailed information gathered from the fMCG combined with ultrasound findings, we could begin discussions about the treatment strategy earlier within the fetal period.

Ethical Approval

The manuscript is about a retrospective case that does not require ethics committee approval at our institution.

Conflicts of Interest

The authors declare that there are no conflicts of interest regarding the publication of this paper.


The authors would like to thank Mr. Kuniomi Ogata for support of fMCG data analysis and Mr. Thomas D. Mayers for native-speaker revision.


  1. A. W. Liao, R. Snijders, L. Geerts, K. Spencer, and P. K. H. Nicolaides, “Fetal heart rate in chromosomally abnormal fetuses,” Ultrasound in Obstetrics and Gynecology, vol. 16, no. 7, pp. 610–613, 2000. View at: Publisher Site | Google Scholar
  2. W. Sepulveda, A. E. Wong, and V. Dezerega, “First-trimester sonographic findings in trisomy 18: a review of 53 cases,” Prenatal Diagnosis, vol. 30, no. 3, pp. 256–259, 2010. View at: Publisher Site | Google Scholar
  3. M. Arnestad, L. Crotti, T. O. Rognum et al., “Prevalence of long-QT syndrome gene variants in sudden infant death syndrome,” Circulation, vol. 115, no. 3, pp. 361–367, 2007. View at: Publisher Site | Google Scholar
  4. L. Crotti, D. J. Tester, W. M. White et al., “Long QT syndrome-associated mutations in intrauterine fetal death,” JAMA - Journal of the American Medical Association, vol. 309, no. 14, pp. 1473–1482, 2013. View at: Publisher Site | Google Scholar
  5. Q. Wang, S. Chen, Q. Chen, X. Wan, J. Shen, G. A. Hoeltge et al., “The common SCN5A mutation R1193Q causes LQTS-type electrophysiological alterations of the cardiac sodium channel,” Journal of Medical Genetics, vol. 41, pp. e66–e66, 2004. View at: Google Scholar
  6. H. Horigome, M. I. Takahashi, M. Asaka, S. Shigemitsu, A. Kandori, and K. Tsukada, “Magnetocardiographic determination of the developmental changes in PQ, QRS and QT intervals in the foetus,” Acta Paediatrica, vol. 89, pp. 64–67, 2000. View at: Google Scholar
  7. J. R. Skinner, S.-K. Chung, D. Montgomery et al., “Near-miss SIDS due to Brugada syndrome,” Archives of Disease in Childhood, vol. 90, no. 5, pp. 528-529, 2005. View at: Publisher Site | Google Scholar
  8. A. Sun, L. Xu, S. Wang et al., “SCN5A R1193Q polymorphism associated with progressive cardiac conduction defects and long QT syndrome in a Chinese family,” Journal of Medical Genetics, vol. 45, no. 2, pp. 127-128, 2008. View at: Publisher Site | Google Scholar
  9. D. L. Wiggins, J. F. Strasburger, N. L. Gotteiner, B. Cuneo, and R. T. Wakai, “Magnetophysiologic and echocardiographic comparison of blocked atrial bigeminy and 2:1 atrioventricular block in the fetus,” Heart Rhythm, vol. 10, no. 8, pp. 1192–1198, 2013. View at: Publisher Site | Google Scholar
  10. J. F. Strasburger, B. Cheulkar, and R. T. Wakai, “Magnetocardiography for fetal arrhythmias,” Heart Rhythm, vol. 5, no. 7, pp. 1073–1076, 2008. View at: Publisher Site | Google Scholar

Copyright © 2017 Lisheng Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

 PDF Download Citation Citation
 Download other formatsMore
 Order printed copiesOrder

Related articles