Neonatal Liver Failure and Congenital Cirrhosis due to Gestational Alloimmune Liver Disease: A Case Report and Literature Review

Figure 1

Simplified diagnostic and management algorithm for acute liver failure in neonates. PT is prothrombin time; INR is international normalized ratio; herpes simplex virus is the most common virus associated with NALF with high mortality rate without early initiation of treatment (cutaneous findings are uncommon); includes respiratory chain defects, errors in fatty acid oxidation, and mitochondrial DNA depletion syndromes; includes hereditary tyrosinemia type 1, galactosemia, and hereditary fructose intolerance; ET is exchange transfusion; IVIG is intravenous immunoglobulin (modified from Taylor and Whitington, 2016).