An Isolated Hypogonadotropic Hypogonadism due to a L102P Inactivating Mutation of KISS1R/GPR54 in a Large Family

Table 1

Patients characteristics.

Patient	II1	II2	II3	III1	III2	III3	III4	III5	IIII1
Sex	F	F	M	F	M	F	F	M	M
Age, years	25	55	45	35	26	17	30	20	4
Puberty	No	No	Yes	No	No	No	No	No	Micropenis
Marriage, years	4	30	25	18	2	2	5	0	0
Children	0	0	5	0	0	1	0	0	0
Infertility treatment	Yes	Yes	Yes	Yes	No	Yes	Yes	No	No
LH					Low	Low			Low
FSH					Low	Low			Low
Treatment					Andro., FSH, hCG	hCG			Andro.

F, female; M, male; LH, luteinizing hormone; FSH, follicle-stimulating hormone; hCG, human chorionic gonadotropin; Andro., depot testosterone.