Case Report
Congenital Cytomegalovirus Infection Presenting with Hyperbilirubinemia and Splenomegaly in a Term Infant with Trisomy 21
Table 1
Common signs and findings suggestive of a congenital cytomegalovirus infection [
14,
19,
20].
| Physical exam findings | Laboratory test findings | Imaging/additional assessments |
| (1) Intrauterine growth restriction | (1) Thrombocytopenia | (1) Head ultrasound imaging | (2) Small for gestational age | (2) Direct hyperbilirubinemia | (i) Ventriculomegaly | (3) Microcephaly | (3) Elevated transaminases | (ii) Periventricular echogenicity | (4) Seizures | (4) Anemia with hemolysis | (iii) Intracerebral calcifications | (5) Hypotonia | (5) CSF pleocytosis, elevated protein | (iv) Cortical malformations | (6) Poor sucking/feeding | | (v) Cerebellar malformations | (7) Unexplained hydrops | | (2) Ophthalmology exam | (8) Hepatomegaly | | (i) Chorioretinitis | (9) Splenomegaly | | (3) Hearing loss on audiology exam | (10) Petechiae | | (i) Sensorineural hearing loss | (11) Jaundice | | (4) Fetal ultrasound with echogenic bowel |
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