Congenital Cytomegalovirus Infection Presenting with Hyperbilirubinemia and Splenomegaly in a Term Infant with Trisomy 21

Table 1

Common signs and findings suggestive of a congenital cytomegalovirus infection [14, 19, 20].

Physical exam findings	Laboratory test findings	Imaging/additional assessments
(1) Intrauterine growth restriction	(1) Thrombocytopenia	(1) Head ultrasound imaging
(2) Small for gestational age	(2) Direct hyperbilirubinemia	(i) Ventriculomegaly
(3) Microcephaly	(3) Elevated transaminases	(ii) Periventricular echogenicity
(4) Seizures	(4) Anemia with hemolysis	(iii) Intracerebral calcifications
(5) Hypotonia	(5) CSF pleocytosis, elevated protein	(iv) Cortical malformations
(6) Poor sucking/feeding		(v) Cerebellar malformations
(7) Unexplained hydrops		(2) Ophthalmology exam
(8) Hepatomegaly		(i) Chorioretinitis
(9) Splenomegaly		(3) Hearing loss on audiology exam
(10) Petechiae		(i) Sensorineural hearing loss
(11) Jaundice		(4) Fetal ultrasound with echogenic bowel