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| Case 1 | Case 2 |
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Characteristics | | | |
Gender | Male | | Female |
Age (years) | 15 | | 14 |
| 1stadmission | 2ndadmission | |
Weight (kg) | 60 | 67 | 50 |
BMI (kg/m2) | 19.59 | 21.88 | 34.72 |
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Signs and symptoms | | | |
Fever | Yes | No | Yes |
Cough, dyspnea | Yes | Yes | Yes |
Sore throat | No | No | Yes |
Decreased appetite | No | Yes | Yes |
Nausea, vomiting | No | No | No |
Diarrhoea | No | No | Yes |
Fatigue | Yes | Yes | Yes |
Headache | Yes | No | Yes |
Rash | Yes | No | Yes |
Desaturation <92% | No | Yes | Yes |
Edema | No | Yes | Yes |
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PICU referral | | | |
Reason of referral | No PICU referral | Respiratory deterioration | Respiratory distress and excessive edema with early signs of shock |
Organ support | None | NIV | Oxygen therapy through nasal cannula |
Pharmacological treatment | None | Vasopressins, antibiotics, diuretics, morphin | Antibiotics, antipyretics, diuretics, intravenous immunoglobulins |
LOS in hospital | 10 | 28 | 23 |
LOS in PICU | 0 | 7 | 10 |
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Imaging result | | | |
Chest X-ray | Normal | Bilateral consolidations | Consolidation left upper lobe |
Chest CT | No | Bilateral consolidations | Pericarditis and bilateral consolidations |
Heart ultrasound | No | (i) Dilated left ventricle, ejection fraction 30–35%. (ii) Diastolic dysfunction grade 1 (iii) Normal right ventricle (iv) Dilated left atrium (v) MI 2/4, TI 1/4, dilated truncus pulmonalis (vi) Pericardial effusion (5 mm), no hemodynamical consequences | (i) Pericarditis with pericardial effusion 15 mm, no hemodynamical consequences |
ECG | Normal | Negative T-waves in the anterior wall with prolonged QT-segment (534 ms) | Peripheral low voltages with flattened T-waves in left precordials |
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Lab results | (i) Lymphopenia (929/mm³) (ii) Thrombocytopenia (116.000/mm³) (iii) CRP 30 mg/L (maximum) (iv) Albumin 31 g/L (v) Normal hepatic enzymes | (i) No lymphopenia/leukopenia (ii) No thrombocytopenia or thrombocytosis (iii) Anemia: hemoglobin 7.3 g/dL (iv) CRP 56.6 mg/L (v) Albumin 26 g/L (vi) Normal hepatic enzymes (vii) Cardiac enzymes: (a) NT-proBNP 155919.0 ng/L (b) Cardiac troponin T 0.314 µg/L (viii) D-dimer 6943 ng/ml (ix) Fibrinogen 482 mg/dL | (i) Lymphopenia (267/mm³) (ii) Thrombocytosis (808.000/mm³) (iii) Hemoglobin 7.6 g/dL (iv) CRP 304.3 mg/L (maximum) (v) Albumin 24 g/L (vi) Cardiac enzymes: (a) NT-proBNP 3228.0 ng/L (b) Cardiac troponin 0.01 mcg/L (vii) D-dimer 3584 ng/ml (viii) Fibrinogen 322 mg/dL |
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Microbiology results | (i) Nasopharyngeal swab: PCR SARS-CoV-2 positive | (i) Nasopharyngeal swab: PCR SARS-CoV-2 negative (ii) Heart biopsy: PCR SARS-CoV-2 negative (iii) SARS-CoV-2 IgG ELISA positive (54.30 AE/mL) | (i) Nasopharyngeal swab: PCR SARS-CoV-2 negative (twice) (ii) SARS-CoV-2 IgG ELISA positive (41.30 AE/mL) |
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