Case Report
Vaginal Bleeding in an Infant with Extreme Prematurity
Table 1
Summary on reported cases of preterm female infants presenting with uterine bleeding.
| | Author (year) | Gestation (weeks) | Corrected age on presentation | Clinical symptoms | LH (IU/L) | FSH (IU/L) | Estradiol (pmol/L) | Management and outcome |
| | Aafke et al. (2013) | 25 | 5 weeks | Vaginal bleeding, breast buds | 6.9 | 4.5 | 964 | Treated with GnRH analog for 15 months, no recurrence of pubertal development after cessation of treatment | | Maria et al. (2016) | 25 | 2.25 months | Vaginal bleeding, breast buds, facial acne, right ovarian cyst | 2 | 5.7 | 253 | Conservative, breast buds decreased in size, and LH and FSH returned to prepubertal levels at 5.5 mo corrected | | Maria et al. (2016) | 24 | 2.5 months | Vaginal bleeding, breast buds, facial acne, left ovarian cyst | 11 | 5.7 | 451 | Conservative, breast buds decreased in size, and LH and FSH returned to prepubertal levels at 6.5 mo corrected | | Gisselle et al. (2017) | 24 | 3.5 months | Vaginal bleeding, breast buds, estrogenized vaginal mucosa, and enlarged labia minora | 1.3 | 3.1 | 458 | Treated with GnRH analog, outcome not stated in the article |
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