Severe SARS-CoV-2 Infection in a Pediatric Patient Requiring Extracorporeal Membrane Oxygenation

Table 1

Hospital course for patient including laboratory studies and medical inventions.

Laboratory studies or intervention	Reference range	Illness day 5	Illness day 6	Illness day 7	Illness day 8	Illness day 9	Illness day 10
		Hospital day 0	Hospital day 1	Hospital day 2	Hospital day 3	Hospital day 4	Hospital day 5
WBC (10^3/mcL)	5.20–9.70	13.68 ⟶ 5.93	18.74	17.76	14.00 ⟶ 4.98	5.72	4.39
Hbg (g/dL)	11.3–14.7	12.2 ⟶ 13.0	10.4	10.5	10.7 ⟶ 10.1	9.9	10.4
Plt (10^3/mcL)	150–500	102 ⟶ 70	69	49	96 ⟶ 44	98	104
ANC (10^3/mcL)	2.00–5.80	4.24 ⟶ 3.62	15.85	16.69	10.64	3.47	2.3
ALC (10^3/mcL)	1.03–2.18	5.34 ⟶ 0.83	1.11	0.53	1.54	1.07	1.08
Neurophil bands (10^3/mcL)	0–1.00	3.28 ⟶ 7.95	0	4.62	1.4	0	0
ESR (mm/hr)	0–20		14	32	44	80	55
CRP (mg/dL)	0–0.9	19		24.8	21.2		14.8
PCT (ng/dL)	<0.1	3.1	8.5	7.9	5.8	10.8
Troponin I (ng/dL)	0–0.119	<0.012		0.049	0.046
BUN (mg/dL)	8–21	14	3	5	10	19	27
Cr (mg/dL)	0.42–0.90	0.74	0.39	0.37	0.41	0.37	0.41
Albumin (g/dL)	3.7–5.6	2.9	2.6	2.5	2.5	2.5	3.1
AST (U/L)	5–30	77	75	71	89	72	101
LDH (mU/L)	340–670	1564	1514	1607	2205	2019	2020
Lactate (mmol/L)	0.50–2.00	5.6	2.00	1.50	1.10	1.40	1.30
D-dimer (mcg/mL)	≤0.48	3.41	3.76	2.71	1.94	1.55	1.70
PT (seconds)	12.0–15.0	16.3	3.76	17.4	17.8	18.0	16.9
Ferritin (ng/dL)	10–70	309	16.3	438	668	637	637
Fibrinogen (mg/dL)	150–400	500	377	459	486	527	486
Antibodies		Azithromicin, levoflaxin, vancomycin	Ceftriaxone, vancomycin	Ceftriaxone	Ceftriaxone	Ceftriaxone
Infusions/transfusion		pRBCs	Platelets, 25% albumin	Platelets	pRBCs, platelets	Platelets
SARS-CoV-2 theraphy			Hydroxychloroquine, convalescent plasma	Hydroxychloroquine	Hydroxychloroquine, IVIG (1 g/kg)	Anakinra	Anakinra
Vasoactive agents		Epinephrin, norepinephrin	Epinephrin	Epinephrin	Epinephrin	Epinephrin

If multiple iterations of the same laboratory studies were obtained on the same day, the representative results are displayed with “ ⟶ ” in between. WBC: white blood cell count, Hgb: hemoglobin, Plt: platelets, ANC: absolute neurophil count, ALC: absolute lymphocyte count, ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, PCT: procalcitonin, BUN: blood urea nitrogen, Cr: creatinine, AST: aspirate aminotransferase, LDH: lactate dehydrogenase, and PT: prothrombin time.