Functional Adrenocortical Adenoma in a Child with Beckwith–Wiedemann Syndrome

Table 5

Cases of adrenocortical adenoma in BWS in the literature review.

Sbragia-Neto L et al.; (2000), Brazil	2-year-old boy with BWS	Signs of virilization such as rapid growth and phallic enlargement with prepubertal testicular size	Elevated levels of androstenedione, dehydroepiandrosterone sulphate, and 17-ketosteroids with normal levels of cortisol	A right virilizing adrenal adenoma
Beauloye V et al. (2000), France	16-month-old girl with BWS	—	Elevated levels of 17-ketosteroids and androgens	Bilateral adrenal adenoma
Mizota M, et al. (2005), Japan	13-year-old girl with BWS	Clinical manifestation of virilization such as acne, voice change, clitoris hypertrophy, and overgrowth	High serum levels of DHEAS and testosterone	A right virilizing adrenal adenoma at age 6 and left adrenocortical adenoma at age 11
Elnaw E. A, et al. (2019), Sudan	4-year-old female with features suggestive of BWS	History of virilization	High levels of testosterone and DHEAS with normal cortisol level	Right adrenocortical adenoma