Late Endocrine Effects after Stem Cell Transplant in a Young Girl with Griscelli Syndrome

Table 1

Endocrinopathies after stem cell transplant.

Endocrinopathies	Incidence
Thyroid dysfunction; (i) Autoimmune thyroid disease; (ii) Hyperthyroidism	30% in pediatric patients, 15% in adults^1; (i) 2.9% after allogenic SCT, 4% after autologous SCT^2; (ii) 1.3% in pediatric study (75% with autoimmunity)^3
Growth impairment	20–85% in pediatric patients^4
Ovarian failure	65–84% in pediatric patients^1
Pubertal failure	57% of prepubescent females^1

¹Dvorak CC, Gracia CR, Sanders JE, et al. NCI, NHLBI/PBMTC first international conference on late effects after pediatric hematopoietic cell transplantation: endocrine challenges-thyroid dysfunction, growth impairment, bone health,and reproductive risks. Bioi Blood Marrow Transplant. 2011; 12:1725–38. ²Au, WY, Lie, AK, Kung AW, et al. Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2005; 35 (4):383–8. ³SagE, Gont; N, Alika ifoglu A, et al. Hyperthyroidism after allogeneic hematopoietic stem cell transplantation: A Report of Four Cases. J Clin Res Pediatr Endocrinol. 2015; 4:349–54.0rio F, et al. The Scientific World Journal. 2014. ⁴Orio F, Muscogiuri G, Palomba S, et al. Endocrinopathies after allogeneic and autologous transplantation of hematopoietic stem cells.Sci World J. 2014; 2014:1–13.