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Case Reports in Psychiatry
Volume 2011, Article ID 563204, 2 pages
Case Report

Role of Donepezil in Autism: Its Conduciveness in Psychopharmacotherapy

Department of Psychiatry, Rohilkhand Medical College, Bareilly, Uttar Pradesh 243006, India

Received 6 September 2011; Accepted 4 October 2011

Academic Editor: F. Jollant

Copyright © 2011 Rohit Kant Srivastava et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A woman consulted psychiatric Out-Patient Department (OPD) for her 5-year and 2-month-old son presenting with typical autistic symptoms like social, behavioural, and communicational ineptitudeness. Subsequent treatment with Donepezil resulted in marked improvement in the aforementioned symptomatology. Recent studies in autistic child have shown diminished acetylcholine and nicotinic receptor activity, thus an acetylcholinergic enhancer, Donepezil, likely accounts for improvement in autistic symptoms. Evidently, the case report consolidates Donepezil role as a potentially useful agent in the treatment of cognitive and behavioural symptoms observed in this disorder.