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Case Reports in Psychiatry
Volume 2012 (2012), Article ID 949256, 3 pages
Case Report

Biperiden Dependence: Case Report and Literature Review

1Department of Internal Medicine, University of Murcia, 30120 Murcia, Spain
2Department of Psychiatry, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109, USA
3Department of Psychiatry, Hospital Virgen de La Arrixaca, University of Murcia, 30120 Murcia, Spain

Received 14 January 2012; Accepted 4 April 2012

Academic Editor: D. Matsuzawa

Copyright © 2012 Fernando Espi Martinez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Anticholinergic drugs are frequently used in psychiatry for the prophylaxis and treatment of extrapiramidal symptoms caused by neuroleptics. Abuse of anticholinergic agents has been reported in patients with psychotic disorders, on treatment with neuroleptics, and polysubstance use disorders. We are reporting the case of a patient who presented with hypoactive delirium as a consequence of biperiden dependence. The clinician must pay special attention to detect anticholinergic misuse in patients presenting with delirium of unknown cause.