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Case Reports in Psychiatry
Volume 2013, Article ID 503601, 3 pages
Case Report

Augmentative Asenapine in a Recurrent Manic Catatonic Patient with Partial Response to Clozapine

Department of Psychiatry, University of Milan, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy

Received 25 June 2013; Accepted 28 August 2013

Academic Editors: J. S. Brar, D. E. Dietrich, and J. Nakamura

Copyright © 2013 Massimiliano Buoli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Catatonia is a severe but treatable neuropsychiatric syndrome known since the middle of the nineteenth century. It has been considered for a long time as a subtype of schizophrenia, even though this association occurs only in 10% of cases. In contrast, it is frequently observed in bipolar patients. First-line treatment consists of benzodiazepines, while in case of resistance electroconvulsive therapy (ECT) and clozapine have shown positive results. In addition, recent studies reported the efficacy of some atypical antipsychotics. The present case shows the clinical response to augmentative asenapine in a catatonic manic patient with a partial response to clozapine.