Case Report
31-Year-Old Female Shows Marked Improvement in Depression, Agitation, and Panic Attacks after Genetic Testing Was Used to Inform Treatment
Table 1
Genes tested using the Genecept Assay.
| Gene | Variant | Functional significance |
| Serotonin transporter (SLC6A4) | Long/short (rs63749047) | Reduced serotonin reuptake | A > G (rs25531) | Serotonin receptor subtype 2C (5HT2C) | −759 C > T (rs3813929) | Altered satiety signaling | Dopamine receptor subtype 2 (DRD2) | 141 C INS/DEL (rs1799732) | Altered binding of dopamine and antipsychotics | Voltage-dependent calcium channel L-type, alpha 1c subunit (CACNA1C) | G > A (rs1006737) | Altered neuronal depolarization | Ankyrin G (ANK3) | C > T (rs10994336) | Dysregulation of sodium channels | Catechol-O-methyltransferase (COMT) | 158 Val > Met (rs4680) | Altered dopamine degradation | Methylenetetrahydrofolate reductase (MTHFR) | 677 C > T (rs1801133) | Impaired folic acid metabolism | Cytochrome P450 2D6 (CYP2D6) | Multiple variations | Variants can lead to poor metabolism, intermediate metabolism, or ultra- metabolism of certain medications | Cytochrome P450 2C19 (CYP2C19) | Multiple variations | Variants can lead to poor metabolism, intermediate metabolism, or ultra- metabolism of certain medications | Cytochrome P450 3A4/5 (CYP3A4/5) | Multiple variations | Increased metabolism of certain medications |
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