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Case Reports in Psychiatry
Volume 2016, Article ID 1657691, 5 pages
Case Report

Alagille Syndrome: A Case Report Highlighting Dysmorphic Facies, Chronic Illness, and Depression

1The Pennsylvania State University College of Medicine, Hershey, PA, USA
2Nishtar Medical College, Multan, Pakistan
3Department of Psychiatry, The Pennsylvania State University College of Medicine, Hershey, PA, USA

Received 14 September 2016; Accepted 8 November 2016

Academic Editor: Liliana Dell'Osso

Copyright © 2016 James J. Bresnahan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Alagille syndrome is a rare multisystem disorder affecting the liver, heart, vertebrae, eyes, and face. Alagille syndrome shares multiple phenotypic variants of other congenital or chronic childhood illnesses such as DiGeorge syndrome, Down syndrome, spina bifida, type 1 diabetes mellitus, and cystic fibrosis. All of these chronic illnesses have well-established links to psychiatric conditions. There are few community resources for Alagille patients, as it is an extremely rare condition. Despite the overlap with other chronic childhood illnesses, the psychiatric manifestations of Alagille syndrome have not been previously discussed in literature. The current study is a case report of a twelve-year-old female hospitalized in our pediatric psychiatric hospital for suicidal ideation with intent and plan. The patient had major depressive disorder, anxiety, other specified feeding and eating disorder, and attention-deficit/hyperactive disorder.