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Case Reports in Psychiatry
Volume 2016, Article ID 3614053, 3 pages
Case Report

Successful Treatment of Suspected Cannabinoid Hyperemesis Syndrome Using Haloperidol in the Outpatient Setting

1Departments of Psychiatry and Internal Medicine, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
2Department of Medicine, Division of General Internal Medicine and Geriatrics, Medical University of South Carolina, 135 Rutledge Avenue, Charleston, SC 29425, USA

Received 29 May 2016; Revised 15 July 2016; Accepted 21 July 2016

Academic Editor: Liliana Dell’Osso

Copyright © 2016 Jennifer L. Jones and Karen E. Abernathy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chronic use of cannabis can result in a syndrome of hyperemesis characterized by cyclical vomiting without any other identifiable causes. Cannabinoid hyperemesis syndrome (CHS) is seldom responsive to traditional antiemetic therapies. Despite frequent nausea and vomiting, patients may be reluctant to discontinue use of cannabis. We report a case of severe, refractory CHS with complete resolution of nausea and vomiting after treatment with haloperidol in the outpatient setting. After review of the literature, we believe this is the first reported successful outpatient treatment of CHS and suggests a potential treatment for refractory patients.