Quetiapine-Induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Table 1

The criteria required for the diagnosis of SIADH and the main clinical and laboratory findings of the presented case, which led to the diagnosis of the syndrome.

Criteria needed for SIADH diagnosis	Patient’s laboratory and clinical findings
(1) Decreased plasma osmolality (<275 mOsm/kg)	Plasma osmolarity 243 mOsm/L (275–295 mOsm/L)
(2) Inappropriately concentrated urine (>100 mOsm/kg)	Urine osmolality 264 mOsm/kg
(3) Being euvolemic	The patient was normotensive (blood pressure 130/85 mmHg). Physical examination did not reveal any abnormal findings. Peripheral oedema was absent
(4) Elevated urine Na (>20 mEq/L)	Urine Na concentration 68 mEq/L
(5) Euthyroid, eucortisolemic, and no diuretic use.	Renal, liver, and thyroid function tests and cortisol levels were within the normal limits. Comedication was not present. Patient’s medical history was unremarkable for chronic diseases