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Case Reports in Psychiatry
Volume 2017 (2017), Article ID 7582780, 8 pages
Case Report

Management of Severe Developmental Regression in an Autistic Child with a 1q21.3 Microdeletion and Self-Injurious Blindness

1Department of Child and Adolescent Psychiatry, Reference Centre for Rare Psychiatric Diseases, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Université Pierre et Marie Curie, 47-83 Bd de l’Hôpital, 75013 Paris, France
2Department of Pediatric Neurology, AP-HP, Hôpital Armand-Trousseau, 26 Avenue du Dr. Arnold Netter, 75012 Paris, France
3Department of Genetics, Division of Chromosomal Genetics, AP-HP, Hôpital Armand-Trousseau, 26 Avenue du Dr. Arnold Netter, 75012 Paris, France
4INSERM U669, Maison de Solenn, Paris, France
5Institut des Systèmes Intelligents et Robotiques, CNRS UMR 7222, Université Pierre et Marie Curie, 1 Place Jussieu, 75005 Paris, France

Correspondence should be addressed to Cora Cravero

Received 11 November 2016; Revised 16 February 2017; Accepted 23 March 2017; Published 25 May 2017

Academic Editor: Toshiya Inada

Copyright © 2017 Cora Cravero et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report the case of a young boy with nonverbal autism and intellectual disability, with a rare de novo 1q21.3 microdeletion. The patient had early and extreme self-injurious behaviours that led to blindness, complicated by severe developmental regression. A significant reduction in the self-injurious behaviours and the recovery of developmental dynamics were attained in a multidisciplinary neurodevelopmental inpatient unit. Improvement was obtained after managing all causes of somatic pains, using opiate blockers and stabilizing the patient’s mood. We offered both sensorimotor developmental approach with therapeutic body wrap and specific psychoeducation adapted to his blindness condition for improving his communication abilities.