Polypharmacy Leading to Priapism in HIV Patient with Schizoaffective Disorder: A CYP450 Cascade

Table 1

List of drugs metabolized by cytochrome P450 enzymes.

Drug	Substrate	Inducer	Inhibitor
Sertraline	2D6,2C9/19	-	2D6(weak)
Bupropion	2B6	-	2D6
Trazodone	3A4,2D6	-	-
Aripiprazole	3A4,2D6	-	-
NNRTIs
Nevirapine	3A4, 2B6	3A4	3A4,2D6,2C9/19
Efavirenz	3A4, 2B6	3A4	3A4,2D6,2C9/19
Delaverdine	3A4, 2B6	3A4	3A4
Protease inhibitors
Ritonavir	3A4, 2D6	2C9/19, 1A2	2D6, 3A4 (strongest)
Indinavir	3A4, 2D6	-	3A4
Nelfinavir	3A4, 2D6	-	3A4
Squanavir	3A4, 2D6	-	3A4 (weakest)