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| Patient 5 | Patient 6 | Patient 7 | Patient 8 | Patient 9 | Patient 10 | Patient 11 |
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Sex, age | Male, 10 years | Male, 8 years | Male, 8 years | Male, 9 years | Male, 15 years | Male, 7 years | Male, 12 years |
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Main reason for referral | Learning difficulties | Learning difficulties | Learning difficulties | Intermittent explosive behaviour; ADHD | Confirmation of ASD (ADOS-ADI-R) | Suspicion of ADHD | Mood disorder |
Anxiety symptoms | Behavioural difficulties | Hyperactivity sleep; family related issues | NF1 complications: Precocious puberty; nondysplastic scoliosis; UBOs: cerebellum, globus pallidus | Emotional lability | NF1 related stress | Learning difficulties |
Social difficulties | | | | | | |
Outpatient unit | Outpatient unit | Outpatient unit | Outpatient unit | Outpatient unit | Outpatient unit | Outpatient unit |
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NF1 diagnosis | Familial NF1 | Familial NF1 | Sporadic NF1 | Sporadic NF1 | Sporadic NF1 | Sporadic NF1 | Legius SD |
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Developmental delay | Minor (graphic abilities) | No | Minor (global motor) | Walking unstable at 21 months | ??? | No | Not reported |
Repeated otitis | | Prematurity | Speech delay (Repeated otitis) | | | |
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Cognitive assessment WISC-IV | Verbal: 92; performance: 121; working memory: 97; speed: 88 | Verbal: 86; performance: 77; working memory: 73; speed: 71 | Verbal: 92; performance: 94; working memory: 76; speed: 78 | Verbal: 98; performance: 65; working memory: 82; speed: 83 | Verbal: 86; performance: 73; working memory: 109; speed: 100 | Verbal: 92; performance: 109; working memory: 91; speed: 103 | Verbal: 94; performance: 90; working memory: 73; speed: 66 |
Heterogeneous | Heterogeneous | Heterogeneous | Heterogeneous | Heterogeneous | Heterogeneous | Heterogeneous |
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Attention and executive functions | Divided attention TEA-Ch: −2SD | Divided attention TEA-Ch: −1.4SD | Divided attention TEA-Ch: Normal | Divided attention TEA-Ch: −0.5SD | | Divided attention TEA-Ch: +0.7SD | |
Unimodal attention TEA-Ch: Normal | Unimodal attention TEA-Ch: −1.4SD | Unimodal attention TEA-Ch: Normal | | Unimodal attention TEA-Ch: −0.7SD | Unimodal attention: TEA-Ch +0.3SD | Unimodal attention TEA-Ch: −0.7SD |
| Sustained attention TEA-Ch: −1.7SD | | | | | |
| Attention control TEA-Ch: -2.2SD | Attention control TEA-Ch: +0.7SD | | | | |
| Inhibition TEA-Ch: −2SD | | | | Inhibition TEA-Ch: +1SD | |
Flexibility NEPSY-II: −0.1SD | Flexibility NEPSY-II: −1.5SD | Flexibility NEPSY-II: −0.5SD | Flexibility NEPSY-II: −1.5SD | Flexibility NEPSY-II: −1.4SD | Flexibility NEPSY-II: −0.1SD | Flexibility NEPSY-II: −0.2SD |
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Memory | Short-term NEPSY-II: −0.1SD | Short-term NEPSY-II: −1.2SD | Short-term: −1.6SD | | Short-term NEPSY-II: −0.3SD | Short-term NEPSY-II: −0.7SD | Short-term NEPSY-II: −0.3SD |
Episodic REY: −0.3SD | Episodic REY: +0.5SD | | | | Episodic REY: +0.4SD | Episodic REY: −3SD |
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Language assessment EXALANG | Oral receptive: -0.7SD | Oral receptive: −1.5SD | Oral expressive: +1.4SD | Normal | Normal | Normal | Oral lexicon: −1.3SD |
Oral expressive: −0.5SD | Oral expressive: −2SD | Oral lexicon: −0.5SD | | | | |
Oral lexicon: +0.7SD | Oral lexicon: −1.2SD | | | | | |
Written receptive: −2.6SD | Written expressive: −1.7SD | Written receptive: +1.4S | | | | Written expressive: −2.6 |
Written expressive: −2.9SD | | Written expressive: −0.5SD | | | | |
Spelling: −2.6SD | | | | | | |
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Motricity | Visuo-construction REY: +0.5SD | Visuo-construction REY: Normal | Visuo-construction REY: −0.7SD | Visuo-construction REY: −3SD | Visuo-construction REY: −0.3SD | Visuo-construction REY: +0.2SD | Visuo-construction REY: −0.7SD |
Visuo-spatial NEPSY-II: +0.5SD | Visuo-spatial NEPSY-II: −0.6SD | Visuo-spatial NEPSY-II: −0.3SD | Visuo-spatial NEPSY-II: −0.1SD | Visuo-spatial NEPSY-II: −0.8SD | Visuo-spatial NEPSY-II: +0.3SD | Visuo-spatial NEPSY-II: −0.8SD |
Graphomotor skill BHK: −2.3SD | Graphomotor skill BHK: −2SD | Graphomotor skill BHK: −2SD | Graphomotor skill BHK: −2SD | Graphomotor skill BHK: +1.4SD | Graphomotor skill BHK: +0.4SD | Graphomotor skill BHK: −0.3SD |
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Socio-cognition/pragmatic | −0.7SD | −0.3SD | | | −2.2SD | −1SD | Normal |
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Psychiatric Diagnosis | ADHD-inattentive type | Borderline intelligence | Anxious disorder | Borderline intelligence | ASD (Asperger) | Anxiety disorder | Mood disorder |
Dyslexia | ADHD-impulsive type | Motor (graphic) delay | ADHD, ODD | Dysexecutive profile | | Attachment disorder |
Pragmatic communication disorder | Dysexecutive profile | | Visual-Spatial Dyspraxia | Dyspraxia | | Written language difficulties |
| At risk for dyslexia | | Dysgraphia | | | NF1 related stress |
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Medication | Methylphenidate | Methylphenidate (not well tolerated) | Melatonin | Methylphenidate | Aripiprazole | None | Quetiapine |
Triptorelin Acetate |
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Nonpharmacological treatment | Specific school adaptations | Specific school adaptations | | Specific school adaptations | Specific school adaptations | | |
Speech and reading therapy | Speech and reading therapy | | Speech and reading therapy (past) | Language and motor remediation in the past | | Speech and reading therapy |
Motor skills remediation | Motor skills remediation | Motor skills remediation | Motor skills remediation | Social strategies group | | |
| | Psychotherapy | Psychodrama therapy | | Psychotherapy | Psychiatric follow-up |
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Outcome | Improvement | Improvement | Stable | Improvement | Stable | Stable | Stable |
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