Clinical Relevance of Pharmacogenetics in Serotonin Syndrome

Table 1

Patient’s pharmacogenetic tests done with genotype and phenotype results.

Gene	Genotype	Phenotype
CYP3A4^a	1/22	Intermediate metabolizer
CYP3A5^b	1/3	Intermediate metabolizer
CYP2B6^c	1/6	Intermediate metabolizer
CYP2C9^d	1/2	Intermediate metabolizer
CYP2C19^e	1/2	Intermediate metabolizer
CYP2D6 ^f	4/41	Intermediate metabolizer
COMT^g	Val158Met A/A	Low COMT activity
HTR2C^h	-759C > T C/C	Homozygous for the C allele (rs3813929)
HTR2C^h	114138144C > G C/C	Homozygous for the C allele (rs1414334)
DRD2^i	Taq1A A/G	Altered DRD2 function
UGT2B15^j	1/1	Normal metabolizer

^aCytochrome P450 family 3 subfamily A member 4. ^bCytochrome P450 family 3 subfamily A member 5. ^cCytochrome P450 family 2 subfamily B member 6. ^dCytochrome P450 family 2 subfamily C member 9. ^eCytochrome P450 family 2 subfamily C member 19. ^fCytochrome P450 family 2 subfamily D member 6. ^gCatechol-O-methyltrasferase. ^h5-Hydroxytryptamine receptor 2C. ⁱDopamine receptor D2. ^jGlucuronosyltransferase family 2 member B15.