Considerations of HLA, Renal Failure, Valproic Acid Use, and Current Treatment Guidelines in Clozapine-Induced Agranulocytosis

Table 1

Treatment course lab table.

Treatment day	Treatment day 0	Treatment day 1	Treatment day 2	Treatment day 3	Treatment day 4	Treatment day 5	Treatment day 6	Treatment day 7	Treatment day 8	Treatment day 9	Treatment day 10	Treatment day 11	Treatment day 12
Lab value
ANC level (μL)	0.05	0	0.01	0.01	0.01	0.01	0	0.02	0.04	0.57	3.97	11.51	10.38
WBC (L)	N/A	0.4	0.4	0.3	0.2	0.3	0.2	0.3	0.4	1.8	7	18.7	N/A
Temperature max	98.8	98.6	100.7	103.1	101	98.5	99.3	97.3	98.1	98.6	97.8	97.7	98.1
BP		127/79	144/77	110/59	113/48	131/59	101/53	129/61	127/65	119/64	130/75	117/65	130/70
Hgb (G/DL)	10.4	9.9	11	10.5	9.8	8.9	8.5	8	8	8.6	9.6	9.3	8.4
Hematocrit (%)	33.8	31.8	36.4	33.6	31.6	29.3	27.2	26.3	26.1	28.1	32.2	30.6	28.6
H&H	10.4/33.8	9.9/31.8	11.0/36.4	10.5/33.6	9.8/31.6	8.9/29.3	8.5/27.2	8.0/26.3	8.0/26.1	8.6/28.1	9.6/32.2	9.3/30.6	8.4/28.6
BUN	N/A	N/A	38	36	46	55	77	70	57	43	33	29	25
CR	N/A	N/A	1.57	1.93	2.3	2.8	3.2	2.45	1.98	1.69	1.75	1.55	1.59
eGFR	N/A	N/A	33.61	26.48	21.63	17.24	14.78	20.11	25.71	30.87	29.65	34.11	33.12
Valproate level	36.5 L			50.9 L
Amlodipine dose	10 mg	10 mg	10 mg	Not given	Not given	10 mg	10 mg	10 mg	Refused	10 mg	10 mg	10 mg	10 mg
Docusate dose	Refused	200 mg	200 mg	200 mg	200 mg	200 mg	200 mg	200 mg	200 mg	200 mg	200 mg	200 mg	200 mg
PEG dose	17 grams	17 grams
Valproate dose	500 mg t.i.d	500 mg t.i.d	500 mg t.i.d	500 mg t.i.d	500 mg t.i.d	500 mg t.i.d	500 mg t.i.d	500 mg t.i.d	500 mg t.i.d	500 mg t.i.d	500 mg t.i.d	500 mg t.i.d	500 mg t.i.d
Filgrastim dose	N/A	300 mcg	300 mcg	800 mcg	800 mcg	800 mcg	N/A	N/A	800 mcg	N/A	N/A	N/A	N/A