Deep Vein Thrombosis after Lithium Toxicity: A Report of Two Cases and Literature Review

Table 1

Changes in laboratory findings prior to the onset of deep vein thrombosis.

(a)

Case 1
Day	1	2	3	4	5	6	7	8	9	10	11
PT (sec)	19.4	18.1	14.5	13.7	13.9	13.4	19.8	15.1	15.4	14.6	14.2
APTT (sec)	30.3	29.1	66.9	58.2	48.4	40.8	28.4	31.5	37.9	40.1	38.8
FDP (μg/mL)	1.3	0.9	2.2	3	4.7	4.7	4.9	6.7	7.7	6.7	11.6
D-dimer (μg/mL)	0.4	0.55	0.75	1.08	1.72	1.57	1.82	2.55	3.05	2.43	5.2
BUN (mg/dL)	10.4	3.1	4.1	5.1	8.8	13.4	26.8	25.1	29.8	25.4	25
SCr (mg/dL)	0.69	0.38	0.61	0.55	0.47	0.52	0.52	0.57	0.52	0.53	0.54
CK (U/L)	40	44	34	56	651	186	298	253	792	398	344
CRP (mg/dL)	0.01	0.03	7.85	12.77	18.9	11.28	2.54	3.38	9.98	10.95	11.26
Li (mEq/L)	3.95	0.99	0.53	0.27	<0.1	—	—	<0.1	—	—	—

(b)

Case 2
Day	-8	-1	1	2	5	7
PT (sec)	—	—	11.8	12.1	12	12
APTT (sec)	—	—	25.2	24.4	22.3	24.5
FDP (μg/mL)	—	—	—	35.5	41.7	31.7
D-dimer (μg/mL)	—	—	—	18.08	19.52	15.56
BUN (mg/dL)	—	—	15.7	11.7	17.2	—
SCr (mg/dL)	—	—	1.03	0.9	0.91	0.83
CK (U/L)	—	—	17	16	21	19
CRP (mg/dL)	—	—	—	0.21	0.03	—
Li (mEq/L)	1.92	1.5	0.98	0.59	—	—

Day 1: date of hospitalization; APTT: activated partial thromboplastin time; BUN: blood urea nitrogen; CK: creatine kinase; CRP: C-reactive protein; FDP: fibrinogen and fibrin degradation products; Li: lithium; PT: prothrombin time; SCr: serum creatinine.