Case Report
Deep Vein Thrombosis after Lithium Toxicity: A Report of Two Cases and Literature Review
Table 1
Changes in laboratory findings prior to the onset of deep vein thrombosis.
(a) |
| Case 1 | Day | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
| PT (sec) | 19.4 | 18.1 | 14.5 | 13.7 | 13.9 | 13.4 | 19.8 | 15.1 | 15.4 | 14.6 | 14.2 | APTT (sec) | 30.3 | 29.1 | 66.9 | 58.2 | 48.4 | 40.8 | 28.4 | 31.5 | 37.9 | 40.1 | 38.8 | FDP (μg/mL) | 1.3 | 0.9 | 2.2 | 3 | 4.7 | 4.7 | 4.9 | 6.7 | 7.7 | 6.7 | 11.6 | D-dimer (μg/mL) | 0.4 | 0.55 | 0.75 | 1.08 | 1.72 | 1.57 | 1.82 | 2.55 | 3.05 | 2.43 | 5.2 | BUN (mg/dL) | 10.4 | 3.1 | 4.1 | 5.1 | 8.8 | 13.4 | 26.8 | 25.1 | 29.8 | 25.4 | 25 | SCr (mg/dL) | 0.69 | 0.38 | 0.61 | 0.55 | 0.47 | 0.52 | 0.52 | 0.57 | 0.52 | 0.53 | 0.54 | CK (U/L) | 40 | 44 | 34 | 56 | 651 | 186 | 298 | 253 | 792 | 398 | 344 | CRP (mg/dL) | 0.01 | 0.03 | 7.85 | 12.77 | 18.9 | 11.28 | 2.54 | 3.38 | 9.98 | 10.95 | 11.26 | Li (mEq/L) | 3.95 | 0.99 | 0.53 | 0.27 | <0.1 | — | — | <0.1 | — | — | — |
|
|
(b) |
| Case 2 | Day | -8 | -1 | 1 | 2 | 5 | 7 |
| PT (sec) | — | — | 11.8 | 12.1 | 12 | 12 | APTT (sec) | — | — | 25.2 | 24.4 | 22.3 | 24.5 | FDP (μg/mL) | — | — | — | 35.5 | 41.7 | 31.7 | D-dimer (μg/mL) | — | — | — | 18.08 | 19.52 | 15.56 | BUN (mg/dL) | — | — | 15.7 | 11.7 | 17.2 | — | SCr (mg/dL) | — | — | 1.03 | 0.9 | 0.91 | 0.83 | CK (U/L) | — | — | 17 | 16 | 21 | 19 | CRP (mg/dL) | — | — | — | 0.21 | 0.03 | — | Li (mEq/L) | 1.92 | 1.5 | 0.98 | 0.59 | — | — |
|
|
Day 1: date of hospitalization; APTT: activated partial thromboplastin time; BUN: blood urea nitrogen; CK: creatine kinase; CRP: C-reactive protein; FDP: fibrinogen and fibrin degradation products; Li: lithium; PT: prothrombin time; SCr: serum creatinine.
|