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Case Reports in Pulmonology
Volume 2012, Article ID 146081, 5 pages
Case Report

Development of Bullous Disease during Treatment of Pulmonary Marginal Zone B-Cell Lymphoma

1Department of Internal Medicine, Wayne State University School of Medicine, 4201 St. Antoine, UHC-2E, Detroit, MI 48201, USA
2Medical Service, John D. Dingell VAMC, Detroit, MI 48201, USA

Received 2 July 2012; Accepted 5 August 2012

Academic Editors: G. Hillerdal and H. Kobayashi

Copyright © 2012 S. Ansari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We describe an unusual case of severe pulmonary bullous disease developing during treatment of marginal zone B-Cell lymphoma (MALT) involving the pulmonary parenchyma. The patient originally presented with pneumonia-like symptoms along with hemoptysis and was diagnosed with MALT lymphoma after a video-assisted thoracic surgical (VATS) lung biopsy. Computed tomography (CT) of the chest at diagnosis revealed multiple opacities, but no bullous disease. During the ensuing 4 years, and while on chemotherapy for the MALT lymphoma, sequential CT and pulmonary function tests revealed the development of progressive bullous disease resulting in the replacement of large portions of the lung parenchyma with bilateral bullae. This complication is rare, has been reported only once before in a patient with concomitant amyloidosis, and may be related to activation of proteolytic enzymes by lymphoma cells or chemotherapeutic agents.