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Case Reports in Pulmonology
Volume 2012 (2012), Article ID 382460, 2 pages
Case Report

Reversible Pulmonary Hypertension Associated with Whipple’s Disease

1U.O. Medicina d’Urgenza e Pronto Soccorso, A. O. Fatebenefratelli, 20123 Milano, Italy
2U.O. Cardiologia, A. O. Fatebenefratelli, 20123 Milano, Italy

Received 13 July 2012; Accepted 5 September 2012

Academic Editors: I. Lang and C. L. Ren

Copyright © 2012 A. Villa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We describe a case of Whipple’s disease with pulmonary hypertension in a 72-year-old woman in whom the pulmonary hypertension resolved completely after antibiotic therapy. She was admitted to study with a 2-months history of weight loss, diarrhoea, abdominal pain, asthenia, inappetence, and fever. She did not have dyspnoea or respiratory symptoms. A casual echocardiogram showed a pulmonary artery systolic pressure of 95 mmHg. Forty days after starting antibiotic therapy, an echocardiogram showed a complete normalisation of right ventricular involvement. Whipple’s disease is a rare and multisystemic disorder in which pulmonary involvement is not a well-known finding. Although Whipple’s disease is not generally considered as a possible cause of pulmonary hypertension, such awareness is important because it may be potentially resolved with antibiotic therapy.