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Case Reports in Pulmonology
Volume 2012, Article ID 836017, 4 pages
http://dx.doi.org/10.1155/2012/836017
Case Report

Diffuse Alveolar Hemorrhage: A Rare Life-Threatening Condition in Systemic Lupus Erythematosus

Department of Internal Medicine, Nassau University Medical Center, East Meadow, NY 11554, USA

Received 30 January 2012; Accepted 6 March 2012

Academic Editors: G. Hillerdal and J. Murchison

Copyright © 2012 Ravi Paul Singh Virdi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. R. Zamora, M. L. Warner, R. Tuder, and M. I. Schwarz, “Diffuse alveolar hemorrhage and systemic lupus erythematosus: clinical presentation, histology, survival, and outcome,” Medicine, vol. 76, no. 3, pp. 192–202, 1997. View at Publisher · View at Google Scholar · View at Scopus
  2. G. W. Hunninghake and A. S. Fauci, “Pulmonary involvement in the collagen vascular diseases,” American Review of Respiratory Disease, vol. 119, no. 3, pp. 471–503, 1979. View at Google Scholar · View at Scopus
  3. W. Emlen, “Systemic lupus erythematosus and mixed connective tissue disease,” Immunology and Allergy Clinics of North America, vol. 13, no. 2, pp. 291–311, 1993. View at Google Scholar · View at Scopus
  4. Y. Santiago-Casas and L. M. Vilá, “Pulmonary hemorrhage in patients with systemic lupus erythematosus,” Current Respiratory Medicine Reviews, vol. 5, no. 1, pp. 49–54, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. D. L. Kamen and C. Strange, “Pulmonary manifestations of systemic lupus erythematosus,” Clinics in Chest Medicine, vol. 31, no. 3, pp. 479–488, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. B. R. Newsome and J. E. Morales, “Diffuse alveolar hemorrhage,” Southern Medical Journal, vol. 104, no. 4, pp. 269–274, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. A. S. Santos-Ocampo, B. F. Mandell, and B. J. Fessler, “Alveolar hemorrhage in systemic lupus erythematosus: presentation and management,” Chest, vol. 118, no. 4, pp. 1083–1090, 2000. View at Google Scholar · View at Scopus
  8. L. A. Barile, L. J. Jara, F. Medina-Rodríguez, J. L. García-Figueroa, and J. M. Miranda-Limón, “Pulmonary hemorrhage in systemic lupus erythematosus,” Lupus, vol. 6, no. 5, pp. 445–448, 1997. View at Google Scholar · View at Scopus
  9. H. Badsha, C. L. Teh, K. O. Kong, T. Y. Lian, and H. H. Chng, “Pulmonary hemorrhage in systemic lupus erythematosus,” Seminars in Arthritis and Rheumatism, vol. 33, no. 6, pp. 414–421, 2003. View at Google Scholar
  10. C. Abud-Mendoza, E. Diaz-Jouanen, and D. Alarcon-Segovia, “Fatal pulmonary hemorrhage in systemic lupus erythematosus. Occurrence without hemoptysis,” Journal of Rheumatology, vol. 12, no. 3, pp. 558–561, 1985. View at Google Scholar · View at Scopus
  11. R. B. Byrd and G. Trunk, “Systemic lupus erythematosus presenting as pulmonary hemosiderosis,” Chest, vol. 64, no. 1, pp. 128–129, 1973. View at Google Scholar · View at Scopus
  12. C. T. Marino and L. P. Pertschuk, “Pulmonary hemorrhage in systemic lupus erythematosus,” Archives of Internal Medicine, vol. 141, no. 2, pp. 201–203, 1981. View at Publisher · View at Google Scholar · View at Scopus
  13. W. D. Travis, T. V. Colby, C. Lombard, and H. A. Carpenter, “A clinicopathologic study of 34 cases of diffuse pulmonary hemorrhage with lung biopsy confirmation,” American Journal of Surgical Pathology, vol. 14, no. 12, pp. 1112–1125, 1990. View at Google Scholar · View at Scopus
  14. M. D. Hughson, Z. He, J. Henegar, and R. McMurray, “Alveolar hemorrhage and renal microangiopathy in systemic lupus erythematosus: immune complex small vascular injury with apoptosis,” Archives of Pathology and Laboratory Medicine, vol. 125, no. 4, pp. 475–483, 2001. View at Google Scholar · View at Scopus
  15. J. W. Leatherman, “Immune alveolar hemorrhage,” Chest, vol. 91, no. 6, pp. 891–897, 1987. View at Google Scholar · View at Scopus
  16. J. L. Myers and A. L. A. Katzenstein, “Microangiitis in lupus-induced pulmonary hemorrhage,” American Journal of Clinical Pathology, vol. 85, no. 5, pp. 552–556, 1986. View at Google Scholar · View at Scopus
  17. E. P. Schwab, H. R. Schumacher, B. Freundlich, and P. E. Callegari, “Pulmonary alveolar hemorrhage in systemic lupus erythematosus,” Seminars in Arthritis and Rheumatism, vol. 23, no. 1, pp. 8–15, 1993. View at Google Scholar · View at Scopus
  18. C. M. Nellessen, U. Pöge, K. A. Brensing, T. Sauerbruch, H. U. Klehr, and C. Rabe, “Diffuse alveolar haemorrhage in a systemic lupus erythematosus patient successfully treated with rituximab: a case report,” Nephrology Dialysis Transplantation, vol. 23, no. 1, pp. 385–386, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. W. H. Koh, J. Thumboo, and M. L. Boey, “Pulmonary haemorrhage in Oriental patients with systemic lupus erythematosus,” Lupus, vol. 6, no. 9, pp. 713–716, 1997. View at Google Scholar · View at Scopus
  20. Y. Makino, M. Ogawa, S. Ueda, and M. Ohto, “CT appearance of diffuse alveolar hemorrhage in a patient with systemic lupus erythematosus,” Acta Radiologica, vol. 34, no. 6, pp. 634–635, 1993. View at Google Scholar · View at Scopus
  21. A. Olson and M. Schwarz, “Diffuse alveolar hemorrhage,” Progress in Respiratory Research, vol. 36, pp. 250–263, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. T. V. Colby, J. Fukuoka, S. P. Ewaskow, R. Helmers, and K. O. Leslie, “Pathologic approach to pulmonary hemorrhage,” Annals of Diagnostic Pathology, vol. 5, no. 5, pp. 309–319, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Y. Tze-Yi, “Diffuse alveolar hemorrhage,” SGH proceedings, vol. 17, no. 2, pp. 94–105, 2008. View at Google Scholar
  24. S. K. Frankel, G. P. Cosgrove, A. Fischer, R. T. Meehan, and K. K. Brown, “Update in the diagnosis and management of pulmonary vasculitis,” Chest, vol. 129, no. 2, pp. 452–465, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. K. I. Hoshi, M. Matsuda, M. Ishikawa et al., “Successful treatment of fulminant pulmonary hemorrhage associated with systemic lupus erythematosus,” Clinical Rheumatology, vol. 23, no. 3, pp. 252–255, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. D. F. Huang, S. T. Tsai, and S. R. Wang, “Recovery of both acute massive pulmonary hemorrhage and acute renal failure in a systemic lupus erythematosus patient with lupus anticoagulant by the combined therapy of plasmapheresis plus cyclophosphamide,” Transfusion Science, vol. 15, no. 3, pp. 283–288, 1994. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Claridge, P. Das, A. Dorling, and M. Robson, “Plasmapheresis as rescue therapy for systemic lupus erthyematosus-associated diffuse alveolar haemorrhage,” BMJ Case Reports. In press.
  28. C. Cañas, G. J. Tobón, M. Granados, and L. Fernández, “Diffuse alveolar hemorrhage in Colombian patients with systemic lupus erythematosus,” Clinical Rheumatology, vol. 26, no. 11, pp. 1947–1949, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. S. J. Chang, Y. S. Yen, A. P. Huo, S. S. Lee, and D. F. Huang, “Acute massive pulmonary hemorrhage after craniotomy in a patient with systemic lupus erythematosus,” Journal of Microbiology, Immunology and Infection, vol. 38, no. 1, pp. 69–72, 2005. View at Google Scholar · View at Scopus
  30. J. E. Gottenberg, L. Guillevin, O. Lambotte et al., “Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases,” Annals of the Rheumatic Diseases, vol. 64, no. 6, pp. 913–920, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. M. J. Leandro, G. Cambridge, J. C. Edwards, M. R. Ehrenstein, and D. A. Isenberg, “B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients,” Rheumatology, vol. 44, no. 12, pp. 1542–1545, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Vigna-Perez, B. Hernández-Castro, O. Paredes-Saharopulos et al., “Clinical and immunological effects of Rituximab in patients with lupus nephritis refractory to conventional therapy: a pilot study,” Arthritis Research and Therapy, vol. 8, no. 3, p. R83, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. C. B. Narshi, S. Haider, C. M. Ford, D. A. Isenberg, and I. P. Giles, “Rituximab as early therapy for pulmonary haemorrhage in systemic lupus erythematosus,” Rheumatology, vol. 49, no. 2, pp. 392–394, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. C. Abud-Mendoza, R. Moreno-Valdés, E. Cuevas-Orta et al., “Treating severe systemic lupus erythematosus with rituximab. An open study,” Reumatologia Clinica, vol. 5, no. 4, pp. 147–152, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Estella, A. Jareno, and L. Perez-Bello, “Intrapulmonary administration of recombinant activated factor VII in diffuse alveolar haemorrhage: a report of two case,” Cases Journal, vol. 1, article 150, 2008. View at Publisher · View at Google Scholar
  36. L. Heslet, J. D. Nielsen, M. Levi, H. Sengeløv, and P. I. Johansson, “Successful pulmonary administration of activated recombinant factor VII in diffuse alveolar hemorrhage,” Critical Care, vol. 10, p. R177, 2006. View at Publisher · View at Google Scholar · View at Scopus