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Case Reports in Pulmonology
Volume 2012 (2012), Article ID 896409, 3 pages
Case Report

An Unusual Transudative Pleural Effusion Succeeded by Pulmonary and Brain Edema and Death

1Pulmonary Ward, Vali-e-Asr Hospital, Birjand University of Medical Sciences, Birjand 9718766995, Iran
2Neurologic Ward, Vali-e-Asr Hospital, Birjand University of Medical Sciences, Birjand 9718766995, Iran

Received 4 December 2011; Accepted 2 February 2012

Academic Editor: C. L. Ren

Copyright © 2012 Sayyed Gholam Reza Mortazavimoghaddam and H. R. Riasi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Here we report a 22-year old woman with massive and bilateral transudative effusion succeeded by pulmonary edema and brain edema and death. Investigations for systemic disorders were negative. Exacerbation of dyspnea after intravenous fluid infusion was a main problem. As effusion was refractory to medical treatment, the patient was referred for surgical pleurodesis and bilateral surgical pleurodesis were done separately. Postsurgically, dyspnea exacerbation occurred after each common cold infection. Vertigo and high intracranial pressure were also a problem postsurgically. CSF pressure was 225 mm/H2O. Therapeutic lumbar puncture was done in two sequential weeks, and the patient was on acetazolamide 250 mg/trivise a day. Despite the medical treatment, progressive dyspnea, headache, and high intracranial pressure followed by death nine months after pleurodesis. As there is a gradient of pressure between pleura and CSF, after pleurodesis brain edema must be a consequence of inversing this gradient. In conclusion, when there are any abnormalities about fluid volume or pressure in any of these cavities, we have to study other cavities.